Late gadolinium enhancement magnetic resonance imaging for the assessment of myocardial infarction: comparison of image quality between single and double doses of contrast agents
Late gadolinium enhancement magnetic resonance imaging for the assessment of myocardial infarction: comparison of image quality between single and double doses of contrast agents
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DOI：
10.1007/s10554-014-0505-x
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发表时间：
2014-12-01
影响因子：
2.1
通讯作者：
Chung, Jin Wook
中科院分区：
文献类型：
--
作者：
Kim, Yeo Koon;Park, Eun-Ah;Chung, Jin Wook
比较单剂量钆造影剂与常规双剂量钆造影剂在晚期钆增强（LGE）心脏磁共振成像（CMR）中评估心肌梗死的图像质量。本回顾性研究对37例慢性心肌梗死患者行LGE CMR，使用两种不同剂量的钆造影剂：单剂量的0.1 mmol/kg钆- dtpa 17例，双剂量的0.2 mmol/kg 20例，采用倒置恢复（IR）快速低角度拍摄的大小重建和相位敏感图像。比较梗死心肌与正常心肌（cnr梗死-正常，显著性（梗死-正常））和梗死心肌与左心室腔（cnr梗死- lvc，显著性（梗死- lvc））的对比噪声比（CNR）和视觉显著性。观察者间对梗死最大跨壁范围的一致性也进行了评估。双剂量钆造影剂组cnrrnt -normal (15.5 +/- A 20.7比40.4 +/- A 16.1，相敏图像9.5 +/- A 2.8比11.2 +/- A 2.7, P < 0.001)，而显著性（梗死-normal）两组间差异无统计学意义（P < 0.05）。单剂量钆造影剂对cnr梗死- lvc （7.7 +/- A 10.7 vs -6.6 +/- A 19.0, 4.1 +/- A 2.3 vs -0.4 +/- A 4.1, P < 0.05）和显著性（梗死- lvc）均有显著改善。两组在评估梗死跨壁范围方面的观察者间一致性均为中等：单剂量组0.591，双剂量组0.472。与双剂量相比，使用单剂量钆造影剂的LGE CMR显示梗死心肌和左心室腔腔之间的对比度明显更好，而梗死心肌和正常心肌之间的视觉对比度明显降低。
To compare the image quality of late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMR) using a single dose of gadolinium contrast agent versus the conventional double dose for assessing myocardial infarction. This retrospective study examined 37 patients with chronic myocardial infarction who underwent LGE CMR using both inversion recovery (IR)-turbo fast low-angle shot magnitude-reconstructed and phase-sensitive images with two different dosages of gadolinium contrast agent: a single dose of 0.1 mmol/kg gadolinium-DTPA in 17 patients and a double dose of 0.2 mmol/kg in 20 patients. The contrast-to-noise ratio (CNR) and visual conspicuity between infarct and normal myocardium (CNRinfarct-normal, conspicuity(infarct-normal)) and between infarct and left ventricular cavity (CNRinfarct-LVC, conspicuity(infarct-LVC)) were compared. Interobserver agreement for the maximal transmural extent of infarction was also evaluated. CNRinfarct-normal was significantly higher with double-dose gadolinium contrast agent (15.5 +/- A 20.7 vs. 40.4 +/- A 16.1 in magnitude images and 9.5 +/- A 2.8 vs. 11.2 +/- A 2.7 in phase-sensitive images, P < 0.001) while conspicuity(infarct-normal) showed no significant difference between the two groups (P > 0.05). Both CNRinfarct-LVC (7.7 +/- A 10.7 vs. -6.6 +/- A 19.0 in magnitude images and 4.1 +/- A 2.3 vs. -0.4 +/- A 4.1 in phase-sensitive images, P < 0.05) and conspicuity(infarct-LVC) were significantly better with single-dose gadolinium contrast. Interobserver agreement for assessing the transmural extent of infarction was moderate in both groups: 0.591 for single-dose and 0.472 for double-dose. LGE CMR using a single dose of gadolinium contrast agent showed significantly better contrast between infarcted myocardium and left ventricular cavity lumen without a significant decrease in visual contrast between infarcted myocardium and normal myocardium, compared to a double dose.