Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans
Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans
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DOI：
10.1111/j.1469-7793.2001.00925.x
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发表时间：
2001-08-01
影响因子：
5.5
通讯作者：
Sinkjær, T
中科院分区：
文献类型：
--
作者：
Grey, MJ;Ladouceur, M;Sinkjær, T
1. 本研究的目的是确定哪些传入神经会导致比目鱼肌牵张反射的中潜伏期反应，该反应是由人类行走过程中意外扰动引起的。2. 14 名健康受试者在跑步机上以约 3.5 km h(-1) 的速度行走，左脚踝连接有便携式拉伸装置。比目鱼肌牵张反射是通过在足跟接触后200毫秒施加小幅度（类似于8度）背屈扰动来引发的。3．观察到短延迟和中延迟响应，延迟分别为 55 +/- 5 毫秒和 78 +/- 6 毫秒。短潜伏期反应对速度敏感（P < 0.001），而中潜伏期反应则不是（P = 0.725）。4。神经冷却使中潜伏期成分的延迟增加程度高于短潜伏期成分（P < 0.005）。5。缺血显着降低了短潜伏期成分（P = 0.004），而中潜伏期成分则没有变化（P = 0.437）。6。摄入替扎尼定（一种 α (2)-肾上腺素能受体激动剂，已知可选择性抑制第 II 组传入通路中的传递）两小时后，中潜伏期反射被强烈抑制（P = 0.007），而短潜伏期成分没有变化（P = 0.653）7。用盐酸利多卡因进行踝关节阻滞，以抑制足部和踝部的皮肤传入。短潜伏期反射 (P = 0.453) 和中潜伏期反射 (P = 0.310) 均未改变。8．我们的结果支持这样的假设：在行走过程中，由于意外扰动而产生的牵张反射的中潜伏期成分是由第二组肌肉传入引起的。
1. The objective of this study was to determine which afferents contribute to the medium latency response of the soleus stretch reflex resulting from an unexpected perturbation during human walking.2. Fourteen healthy subjects walked on a, treadmill at approximately 3.5 km h(-1) with the left ankle attached to a portable stretching device. The soleus stretch reflex was elicited by applying small amplitude (similar to8 deg) dorsiflexion perturbations 200 ms after heel contact.3. Short and medium latency responses were observed with latencies of 55 +/- 5 and 78 +/- 6 ms, respectively. The short latency response was velocity sensitive (P < 0.001), while the medium latency response was not (P = 0.725).4. Nerve cooling increased the delay of the medium latency component to a greater extent than that of the short latency component (P < 0.005).5. Ischaemia strongly decreased the short latency component (P = 0.004), whereas the medium latency component was unchanged (P = 0.437).6. Two hours after the ingestion of tizanidine, an alpha (2)-adrenergic receptor agonist known to selectively depress the transmission in the group II afferent pathway, the medium latency reflex was strongly depressed (P = 0.007), whereas the short latency component was unchanged (P = 0.653).7. An ankle block with lidocaine hydrochloride was performed to suppress the cutaneous afferents of the foot and ankle. Neither the short (P = 0.453) nor medium (P = 0.310) latency reflexes were changed.8. Our results support the hypothesis that, during walking the medium latency component of the stretch reflex resulting from an unexpected perturbation is contributed to by group II muscle afferents.