Mobile Source Benzene Regulations and Risk of Childhood and Young Adult Hematologic Cancers in Alaska: A Quasi-experimental Study.
Mobile Source Benzene Regulations and Risk of Childhood and Young Adult Hematologic Cancers in Alaska: A Quasi-experimental Study.
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阿拉斯加移动源苯法规与儿童和青年血液癌症的风险：一项准实验研究。
DOI：
10.1097/ede.0000000000001594
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Laden,Francine
中科院分区：
文献类型：
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作者：
Nethery,RachelC;Vega,Sofia;Frazier,ALindsay;Laden,Francine
背景：我们旨在评估 EPA 的移动源空气毒性规则 (MSAT)（针对苯排放）对阿拉斯加儿童和青少年白血病和淋巴瘤发病率的影响。方法：MSAT 于 2011 年实施，使阿拉斯加环境苯含量大幅下降。由于美国大陆之前颁布了与苯相关的法规，MSAT 对其他州的影响相对较小。这创造了本研究中利用的准实验条件。我们使用 2001-2018 年美国各州 2 年儿童和青少年白血病和淋巴瘤的州级发病率，通过应用双重差分方法检查了 MSAT 归因的发病率变化。结果：我们发现了与 MSAT 相关的儿童和青少年淋巴瘤发病率大幅降低的证据（每 100,000 例 –1.23 [–1.84,–0.62] 例），但并非如此白血病（每 100,000 人中有 –0.13 [–0.77, 0.51] 例）。结论：我们的研究结果与 MSAT 降低阿拉斯加苯水平导致儿童和年轻人淋巴瘤发病率下降的假设一致。
Background:We aimed to evaluate the impact of the EPA’s Mobile Source Air Toxics rules (MSAT), which targeted benzene emissions, on childhood and young adult leukemia and lymphoma incidence in Alaska.Methods:MSAT was implemented in 2011 and produced a dramatic decline in ambient benzene in Alaska. Due to previous benzene-related regulations enacted in the continental United States, MSAT had relatively modest impacts in other states. This created quasi-experimental conditions leveraged in this study. Using 2-year state-level incidence rates of childhood and young adult leukemia and lymphoma for each US state 2001–2018, we examined MSAT-attributable changes in incidence by applying a difference-in-differences approach.Results:We found evidence of a substantial reduction associated with MSAT in incidence of childhood and young adult lymphoma (–1.23 [–1.84,–0.62] cases per 100,000), but not in leukemia (–0.13 [–0.77, 0.51] cases per 100,000).Conclusions:Our findings are consistent with the hypothesis that MSAT, which reduced benzene levels in Alaska, led to a decline in lymphoma incidence in children and young adults.