Evidence for a prostate cancer-susceptibillty locus on chromosome 20
Evidence for a prostate cancer-susceptibillty locus on chromosome 20
复制标题
DOI：
10.1086/302994
复制
发表时间：
2000-07-01
影响因子：
9.8
通讯作者：
Schaid, DJ
中科院分区：
文献类型：
--
作者：
Berry, R;Schroeder, JJ;Schaid, DJ
最近的研究表明，遗传性前列腺癌是一种涉及多个易感基因和可变表型表达的复杂疾病，在对162个北美家族进行全基因组搜索时，有大于或等于3名成员患有前列腺癌（PRCA），我们发现了与染色体20q13连锁的证据，在多个位点上两点参数LOD得分>1，标记D20S196的最高两点LOD得分为2.69。在D20 S887，整个数据集的最大多点NPL评分为3.02（P =.002）。根据以前报告的结果，根据存在（n = 116）或不存在（n = 46）男性间传播、平均诊断年龄（
Recent studies suggest that hereditary prostate cancer is a complex disease involving multiple susceptibility genes and variable phenotypic expression, While conducting a genomewide search on 162 North American families with greater than or equal to 3 members affected with prostate cancer (PRCA), we found evidence for linkage to chromosome 20q13 with two-point parametric LOD scores >1 at multiple sites, with the highest two-point LOD score of 2.69 for marker D20S196. The maximum multipoint NPL score for the entire data set was 3.02 (P =.002) at D20S887, On the basis of findings from previous reports, families were stratified by the presence (n = 116) or absence (n = 46) of male-to-male transmission, average age of diagnosis (