Functional imaging of developmental and adaptive changes in neurocognition
Functional imaging of developmental and adaptive changes in neurocognition
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DOI：
10.1016/j.neuroimage.2005.10.007
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发表时间：
2006-04-15
期刊：
影响因子：
5.7
通讯作者：
Gaillard, WD
中科院分区：
文献类型：
--
作者：
Berl, MM;Vaidya, CJ;Gaillard, WD
通过功能性磁成像（fMRI）在典型或发育不良的人群中表征脑行为关系提出了方法和解释的挑战。我们认为，理论，方法和人为因素，影响儿童的发展和适应性变化的特点。从解剖和生理大脑发育研究的结果突出，因为它们可能会影响功能成像结果。然后，我们考虑在发育过程以及神经系统疾病的背景下的功能激活的几种模式。关于认知网络发展的假设被提出来解释正常和非典型发展中的个体差异。我们还确定了与实验设计和任务性能相关的不必要的可变性的潜在来源，并提出了可能的解决方案，以帮助最大限度地减少这些影响。最后，目前研究的一个挑战是缺乏群体和个体分析方法，这些方法可以可靠地应用于捕获和量化导致发育和疾病过程引起的变异性的因素。我们回顾了当前的方法，并提出了潜在的解决方案。(c)2005年爱思唯尔公司All rights reserved.
Characterization of brain-behavior relationships through functional magnetic imaging (fMRI) within typically or atypically developing populations poses methodological and interpretational challenges. We consider theoretical, methodological, and artifactual factors that influence characterization of developmental and adaptive changes in childhood. Findings from anatomical and physiological brain development studies are highlighted as they may influence functional imaging results. Then, we consider several patterns of functional activation within the context of developmental processes as well as neurologic disease. Hypotheses regarding the development of cognitive networks are proposed to account for the individual differences seen in normal and atypical development. We also identify potential sources of unwanted variability related to experimental design and task performance and suggest possible solutions to help minimize these effects. Lastly, a challenge for current studies is a lack of group and individual analysis methods that can be reliably applied to capture and quantify factors that contribute to variability introduced by developmental and disease processes. We review current methods and propose potential solutions. (c) 2005 Elsevier Inc. All rights reserved.