A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery
A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery
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DOI：
10.1016/j.addma.2020.101815
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发表时间：
2021-02-01
影响因子：
11
通讯作者：
Podoleanu, Adrian
中科院分区：
文献类型：
--
作者：
Economidou, Sophia N.;Uddin, Md Jasim;Podoleanu, Adrian
药物递送装置的进步对于患者治疗的个体化和医疗保健的改善至关重要。在这里，我们介绍了3DMNMEMS，这是一种结合了3D打印，微针（MN）和微机电系统（MEMS）的新型设备，允许用户进行多功能和可控的透皮药物输送。中空MN使用立体光刻设计和3D打印，然后集成到MEMS中。通过采用先进的成像技术，我们监测了真实的时间内的皮肤组织内的设备提供的液体的分布。体内测试显示，与皮下注射相比，使用3DMNMEMS递送胰岛素实现了对糖尿病动物的改善的血糖控制。这些结果证明了3DMNMEMS作为用于个性化护理的通用透皮给药系统的潜力。
The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.