Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction
Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction
复制标题
DOI：
10.1016/s0002-9378(97)70205-9
复制
发表时间：
1997-08-01
影响因子：
9.8
通讯作者：
Ward, K
中科院分区：
文献类型：
--
作者：
DizonTomson, DS;Meline, L;Ward, K
目的：因子V Leiden突变是血栓形成最常见的遗传易感性。然而，关于突变携带者的生殖结果或这种血栓性突变的产前表达性知之甚少。我们的目的是研究这种突变是否表现为流产或特发性胎盘血栓形成。研究设计：我们进行了两项研究。首先，进行了病例对照比较，以确定携带因子V Leiden突变的胎儿或母亲是否有自然流产的风险，其次，进行了一项评估携带该突变的胎儿胎盘梗死的队列研究。结果：我们发现139例流产中有12例（8.6%）胎儿携带因子V Leiden的频率增加了两倍，而在产房和分娩房中未选择的孕妇中有17例（4.2%）胎儿携带因子V Leiden的频率增加了两倍，更值得注意的是，24例胎盘梗死中有10例（42%）胎儿携带因子V Leiden的频率增加了10倍，而372例胎盘梗死中有7例（1.9%）
OBJECTIVES: The factor V Leiden mutation is the most common genetic predisposition to thrombosis. However, little is known concerning the reproductive outcome of mutation carriers or prenatal expressivity of this thrombogenic mutation. Our purpose was to examine whether this mutation presents phenotypically as miscarriage or idiopathic placental thrombosis.STUDY DESIGN: We performed two studies. First, a case-control comparison to determine whether fetal or maternal carriers of the factor V Leiden mutation are at risk for spontaneous miscarriage was performed, and, second, a cohort study evaluating placental infarction in fetuses carrying this mutation was performed.RESULTS: We found a twofold increase in the factor V Leiden carrier frequency in 12 of 139 (8.6%) abortuses compared with 17 of 403 (4.2%) unselected pregnant women seen in the labor and delivery suite and, even more remarkable, a tenfold increase in the fetal carrier frequency in 10 of 24 (42%) placentas with >10% placental infarction compared with 7 of 372 (1.9%) placentas with