Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study
Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study
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DOI：
10.1371/journal.pone.0005272
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发表时间：
2009-04-30
期刊：
影响因子：
3.7
通讯作者：
Celum, Connie
中科院分区：
文献类型：
--
作者：
Lingappa, Jairam R.;Kahle, Erin;Celum, Connie
背景资料：Partners HSV-2/HIV-1传播研究（Partners研究）是一项III期、安慰剂对照试验，在HIV-1/HSV-2合并感染者中每日使用阿昔洛韦抑制生殖器疱疹（HSV-2），以减少HIV-1向其HIV-1易感性伴侣的传播，该研究需要招募HIV-1血清不一致的异性伴侣。我们描述的基线特征，本cohol.Methods：HIV-1血清不一致的异性恋夫妇，其中HIV-1感染的合作伙伴是HSV-2血清阳性，有一个CD4计数>= 250细胞/MCL，并没有对抗逆转录病毒治疗，在东部和南部非洲的14个网站注册。人口统计学，行为，临床和实验室特征进行了assessed.Results：3408 HIV-1血清不一致的夫妇登记，67%的HIV-1感染的合作伙伴是女性。夫妇同居的中位数为5年（范围2 - 9），28%的人在入组前一个月报告了无保护措施的性行为。在HIV-1易感参与者中，86%的女性和59%的男性HSV-2血清阳性。其他实验室诊断的性传播感染并不常见（<5%），除了14%的HIV-1感染妇女中有阴道毛滴虫。HIV-1感染受试者的中位基线CD4计数为462个细胞/mcL，中位HIV-1血浆RNA为4.2 log（10）拷贝/mL。调整年龄和非洲地区后，HIV-1 RNA水平的相关因素包括男性（+0.24 log（10）拷贝/mL; p，0.001）和CD4计数（CD4 350 - 499为-0.25和-0.55 log（10）拷贝/mL，相对于
Background: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort.Methods: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count >= 250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed.Results: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2-9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory-diagnosed sexually transmitted infections were uncommon (< 5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462cells/mcL and median HIV-1 plasma RNA was 4.2 log(10) copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+ 0.24 log(10) copies/mL; p, 0.001) and CD4 count (-0.25 and-0.55 log(10) copies/mL for CD4 350-499 and >500 relative to