Fractionating the left frontal response to tools: Dissociable effects of motor experience and lexical competition
Fractionating the left frontal response to tools: Dissociable effects of motor experience and lexical competition
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DOI：
10.1162/089892906775783723
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发表时间：
2006-02-01
影响因子：
3.2
通讯作者：
Thompson-Schill, SL
中科院分区：
文献类型：
--
作者：
Kan, IP;Kable, JW;Thompson-Schill, SL
许多关于语言进化的理论都认为工具的使用和语言之间存在着密切的（也许是因果的）关系。与这一观点相一致的是，神经成像研究发现，工具知识检索不仅激活了与手部动作有关的左侧运动前皮层区域，还激活了一个通常被描述为语言中心的邻近区域。我们研究了这种激活模式是否最好地被描述为与动作和语言相关的单一过程的结果，还是两个独立过程的结果。我们确定了两个不同的神经组成部分共同促成了这种反应：一个位于运动前皮层的后部区域，响应运动知识检索；一个位于左额盖的前部区域，响应词汇竞争。对于解释运动前反应至关重要的是，运动经验的个体差异与运动前皮层的反应强度高度相关，但与前额叶皮层无关。
A number of theories about the evolution of language posit a close ( and perhaps causal) relationship between tool use and speech. Consistent with this idea, neuroimaging studies have found that tool knowledge retrieval activates not only a region of the left premotor cortex involved in hand action, but also an adjacent region that is typically described as a language center. We examined whether this pattern of activation is best described as the result of a single process, related to both action and language, or the result of two independent processes. We identified two distinct neural components that jointly contribute to this response: a posterior region centered in the premotor cortex, which responds to motor knowledge retrieval, and an anterior region centered in the left frontal operculum, which responds to lexical competition. Crucial to the interpretation of the premotor response, individual variation in motor experience was highly correlated with the magnitude of the response in the premotor cortex, but not in the prefrontal cortex.