The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin
The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin
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DOI：
10.1098/rstb.2001.1001
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发表时间：
2001-12-29
期刊：
影响因子：
--
通讯作者：
Fodor, E
中科院分区：
文献类型：
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作者：
Brownlee, GG;Fodor, E
1982年，我们通过研究未被抗体中和的突变体，确定了流感病毒A/PR/8/34的血凝素抗原位点，这是1934年从人身上分离出来的H1亚型流感病毒株。四个抗原位点，即Cb， Sa， Sb和Ca，位于三聚体血凝素穗尖附近。根据1918年西班牙流感的血凝素序列，我们现在可以确定1918年至1934年病毒抗原漂移期间血凝素抗原位点的分化程度。这种差异（40%）比1918年西班牙流感和禽流感H1亚型共识序列预测抗原位点的差异（20%）要广泛得多。这些结果支持这样的假设，即1918年人类大流行起源于一种HI亚型禽流感病毒，该病毒在1918年前不久通过突变和/或重组从鸟类传播到人类，并适应于人类。
In 1982 we characterized the antigenic sites of the haemagglutinin of influenza A/PR/8/34, which is an influenza strain of the H1 subtype that was isolated from humans in 1934, by studying mutants which escaped neutralization by antibody. Four antigenic sites, namely Cb, Sa, Sb and Ca, were found to be located near the tip of the trimeric haemagglutinin spike. Based on the sequence of the haemagglutinin of the 1918 Spanish influenza, we can now specify the extent of divergence of antigenic sites of the haemagglutinin during the antigenic drift of the virus between 1918 and 1934. This divergence was much more extensive (40%) than the divergence (20%) in predicted antigenic sites between the 1918 Spanish influenza and an avian H1 subtype consensus sequence. These results support the hypothesis that the human 1918 pandemic originated from an avian virus of the HI subtype that crossed the species barrier from birds to humans and adapted to humans, presumably by mutation and/or reassortment, shortly before 1918.