Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity.
Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity.
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DOI：
10.1038/nmicrobiol.2016.164
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发表时间：
2016-09-19
影响因子：
28.3
通讯作者：
Ooi EE
中科院分区：
文献类型：
--
作者：
Chan KR;Wang X;Saron WAA;Gan ES;Tan HC;Mok DZL;Zhang SL;Lee YH;Liang C;Wijaya L;Ghosh S;Cheung YB;Tannenbaum SR;Abraham SN;St John AL;Low JGH;Ooi EE
疫苗接种在控制儿童病毒性疾病方面取得了显著成就。然而，为了控制新出现的感染，需要将疫苗提供给老年人，与婴儿不同，老年人可能先前感染过相关病毒或接种过相关病毒疫苗，因此具有针对疫苗的交叉反应性抗体。这些交叉反应性抗体是否以及如何影响减毒活疫苗的效力尚不清楚。采用开放标签随机试验设计，研究人员发现，先前接种过灭活日本脑炎疫苗的受试者具有特定范围的交叉反应抗体滴度，接种黄热病疫苗后可增强黄热病（YF）免疫原性。增强交叉反应性抗体的滴度延长了YF疫苗病毒血症，引发了更大的促炎反应，并诱导了激活fc受体信号通路固有的粘附分子，即免疫信号素，促进了免疫细胞的相互作用和运输。我们的研究结果在临床上证明了抗体增强感染，并表明利用交叉反应性抗体可以提高疫苗效力。本文的在线版本（doi:10.1038/nmicrobiol.2016.164）包含补充资料，仅供授权用户使用。用日本脑炎灭活疫苗免疫可产生交叉反应性抗体，增强随后用黄热病减毒活疫苗免疫的免疫原性，在一项临床试验中显示抗体依赖性增强感染。本文的在线版本（doi:10.1038/nmicrobiol.2016.164）包含补充资料，仅供授权用户使用。
Vaccination has achieved remarkable successes in the control of childhood viral diseases. To control emerging infections, however, vaccines will need to be delivered to older individuals who, unlike infants, probably have had prior infection or vaccination with related viruses and thus have cross-reactive antibodies against the vaccines. Whether and how these cross-reactive antibodies impact live attenuated vaccination efficacy is unclear. Using an open-label randomized trial design, we show that subjects with a specific range of cross-reactive antibody titres from a prior inactivated Japanese encephalitis vaccination enhanced yellow fever (YF) immunogenicity upon YF vaccination. Enhancing titres of cross-reactive antibodies prolonged YF vaccine viraemia, provoked greater pro-inflammatory responses, and induced adhesion molecules intrinsic to the activating Fc-receptor signalling pathway, namely immune semaphorins, facilitating immune cell interactions and trafficking. Our findings clinically demonstrate antibody-enhanced infection and suggest that vaccine efficacy could be improved by exploiting cross-reactive antibodies. The online version of this article (doi:10.1038/nmicrobiol.2016.164) contains supplementary material, which is available to authorized users. Immunization with inactivated Japanese encephalitis vaccine generates cross-reactive antibodies that enhance immunogenicity on subsequent immunization with live attenuated yellow fever vaccine, demonstrating antibody-dependent enhancement of infection in a clinical trial. The online version of this article (doi:10.1038/nmicrobiol.2016.164) contains supplementary material, which is available to authorized users.
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DOI：
10.1056/nejmoa1411100
发表时间：
2014-10-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
WHO Ebola Response Team;Aylward B;Barboza P;Bawo L;Bertherat E;Bilivogui P;Blake I;Brennan R;Briand S;Chakauya JM;Chitala K;Conteh RM;Cori A;Croisier A;Dangou JM;Diallo B;Donnelly CA;Dye C;Eckmanns T;Ferguson NM;Formenty P;Fuhrer C;Fukuda K;Garske T;Gasasira A;Gbanyan S;Graaff P;Heleze E;Jambai A;Jombart T;Kasolo F;Kadiobo AM;Keita S;Kertesz D;Koné M;Lane C;Markoff J;Massaquoi M;Mills H;Mulba JM;Musa E;Myhre J;Nasidi A;Nilles E;Nouvellet P;Nshimirimana D;Nuttall I;Nyenswah T;Olu O;Pendergast S;Perea W;Polonsky J;Riley S;Ronveaux O;Sakoba K;Santhana Gopala Krishnan R;Senga M;Shuaib F;Van Kerkhove MD;Vaz R;Wijekoon Kannangarage N;Yoti Z
通讯作者：
Yoti Z
影响因子：
5.4
作者：
Boonnak, Kobporn;Dambach, Kaitlyn M.;Marovich, Mary A.
通讯作者：
Marovich, Mary A.
影响因子：
158.5
作者：
Hadinegoro, S. R.;Arredondo-Garcia, J. L.;Saville, M.
通讯作者：
Saville, M.
影响因子：
168.9
作者：
Buchbinder, Susan P.;Mehrotra, Devon V.;Duerr, Ann;Fitzgerald, Daniel W.;Mogg, Robin;Li, David;Gilbert, Peter B.;Lama, Javier R.;Marmor, Michael;del Rio, Carlos;McElrath, M. Juliana;Casimiro, Danilo R.;Gottesdiener, Keith M.;Chodakewitz, Jeffrey A.;Corey, Lawrence;Robertson, Michael N.
通讯作者：
Robertson, Michael N.
影响因子：
5.8
作者：
Hanson BJ;Boon AC;Lim AP;Webb A;Ooi EE;Webby RJ
通讯作者：
Webby RJ