A structural equation model to examine the clinical features of mild-to-moderate COVID-19: A multicenter Italian study
A structural equation model to examine the clinical features of mild-to-moderate COVID-19: A multicenter Italian study
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DOI：
10.1002/jmv.26354
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发表时间：
2020-08-02
影响因子：
12.7
通讯作者：
Cammaroto, Giovanni
中科院分区：
文献类型：
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作者：
Barillari, Maria Rosaria;Bastiani, Luca;Cammaroto, Giovanni
本研究的目的是评估意大利患者样本中2019年轻中度冠状病毒病（COVID-19）的临床特征，并调查嗅觉和味觉障碍的发生情况。招募疑似（临床诊断）或实验室确诊的COVID-19感染者。患者完成了一项基于调查的问卷，目的是评估他们的流行病学和临床特征，一般耳鼻咽喉症状，嗅觉和味觉障碍。共有294名轻中度COVID-19患者完成了调查（147名女性）。最常见的全身症状包括发热、肌痛、咳嗽和头痛。分别有70.4%和59.2%的患者报告嗅觉和味觉障碍。发现上述两种疾病之间存在显著关联（rs：0.412;P < .001）。11.6%的患者鼻功能障碍发生在其他症状之前，与鼻塞或鼻溢无显著相关性。有趣的是，我们的统计分析没有显示任何显着差异，无论是一般症状或耳鼻咽喉功能，临床诊断组和实验室确诊（聚合酶链反应）组之间。结构方程模型证实了一般症状、合并症和一般耳鼻喉科主诉之间存在显著的标准化路径（P <0.05），而这些因素与嗅觉和味觉改变之间不存在显著相关性。在意大利轻至中度COVID-19患者中，嗅觉和味觉障碍的患病率在疑似和实验室确诊病例中均很高，并揭示了这些临床体征之间的强相关性，无论是否存在一般或耳鼻喉科症状，如鼻塞或鼻漏。
The purpose of this study was to evaluate the clinical features of mild-to-moderate coronavirus disease 2019 (COVID-19) in a sample of Italian patients and to investigate the occurrence of smell and taste disorders. Infected individuals with suspected (clinical diagnosis) or laboratory-confirmed COVID-19 infection were recruited. Patients completed a survey-based questionnaire with the aim of assessing their epidemiological and clinical characteristics, general otorhinolaryngological symptoms, and smell and taste disorders. A total of 294 patients with mild-to-moderate COVID-19 completed the survey (147 females). The most prevalent general symptoms included fever, myalgia, cough, and headache. A total of 70.4% and 59.2% of patients reported smell and taste disorders, respectively. A significant association between the two above-mentioned disorders was found (rs: 0.412;P < .001). Smell disorders occurred before the other symptoms in 11.6% of patients and was not significantly associated with nasal obstruction or rhinorrhea. Interestingly, our statistical analysis did not show any significant difference, either for general symptoms or otorhinolaryngological features, between the clinical diagnosis group and the laboratory-confirmed diagnosis (polymerase chain reaction) group. The structural equation model confirmed significant standardized paths (P < .05) between general symptoms, comorbidities, and general otorhinolaryngological complaints in the absence of a significant correlation between these elements and smell and taste alterations. The prevalence of smell and taste disorders in mild-to-moderate Italian COVID-19 patients is significant both in suspected and laboratory-confirmed cases and reveals a strong correlation between these clinical signs regardless of the presence of general or otorhinolaryngological symptoms, such as nasal obstruction or rhinorrhea.