Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c)
Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c)
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DOI：
10.1080/15513815.2020.1761491
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发表时间：
2020-05-03
影响因子：
1.1
通讯作者：
Finger, Leron
中科院分区：
文献类型：
--
作者：
Craver, Randall;Huber, Samantha;Finger, Leron
背景资料：心脏损害在SARS-CoV-2患者中经常被提及，通常通过酶升高来诊断，并且通常被认为是由于潜在的冠状动脉疾病。有文献提到冠状病毒伴随心肌病，但尚未得到组织学证实。病例报告：一名先前健康的17岁男性在头痛、头晕、恶心和呕吐2天后因完全心脏骤停到急诊科就诊。尸检显示心脏肥大松弛伴嗜酸性心肌炎。无间质性肺炎或弥漫性肺泡损伤。尸检鼻咽拭子检测到严重急性呼吸道综合征冠状病毒2（SARS-CoV-2），已知引起2019冠状病毒病（COVID-19）。未阐明嗜酸性心肌炎的其他原因。结论：SARS-CoV-2与其他病毒一样，可能与暴发性心肌炎有关。
Background: Cardiac damage is frequently referred to in patients with SARS-CoV-2, is usually diagnosed by enzyme elevations, and is generally thought to be due to underlying coronary artery disease. There are references to cardiomyopathies accompanying coronavirus, but there has been no histologic confirmation. Case report: A previously healthy 17 year male old presented in full cardiac arrest to the emergency department after a 2 day history of headache, dizziness, nausea and vomiting. Autopsy demonstrated an enlarged flabby heart with eosinophilic myocarditis. There was no interstitial pneumonia or diffuse alveolar damage. Postmortem nasopharyngeal swabs detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) known to cause coronavirus disease 2019 (COVID-19). No other cause for the eosinophilic myocarditis was elucidated. Conclusion: Like other viruses, SARS-CoV-2 may be associated with fulminant myocarditis.