The respiratory epithelium. V. Histogenesis of lung carcinomas in the human.
The respiratory epithelium. V. Histogenesis of lung carcinomas in the human.
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呼吸道上皮。
DOI：
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发表时间：
1978
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影响因子：
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通讯作者：
B. Trump
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文献类型：
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作者：
E. Mcdowell;J. Mclaughlin;Dezso K. Merenyi;R. Kieffer;C. Harris;B. Trump
本文应用光镜、电镜及光镜组织化学方法对100例原发性肺癌进行了研究。肿瘤进行组织发生学分类，并根据其细胞来源分为三大类：1）基底细胞和/或粘液细胞肿瘤; 2）神经分泌细胞肿瘤; 3）克拉拉细胞肿瘤。大多数癌（88%）来自基底和/或粘液细胞。这些被细分为表皮样癌（21%），表皮样癌和腺癌（46%），腺癌（21%）。表皮样分化的标准包括张力丝束的存在，不发达的内质网和高尔基体，和发达的桥粒。腺分化的标准包括发育良好的内质网和高尔基体，发育不良的桥粒，细胞外和/或细胞内肺泡的存在，和/或细胞分泌的其他证据，如分泌颗粒。在腺癌细胞外肺泡，典型的连接复合物也存在于管腔方面的细胞顶点接壤的肺泡。根据这些标准，合并表皮样癌和腺癌是最常见的肺癌类型。我们预计，新的数据将澄清类别，如小细胞间变性癌和大细胞癌的世界卫生组织分类。此外，肺肿瘤的组织发生学分型在肺癌危险因素、预后、预防和治疗的研究中可能具有价值。
One hundred human primary lung carcinomas were studied by light and electron microscopy and by light microscopic histochemistry to demonstrate mucosubstances. The tumors were classified histogenetically and were grouped into three major categories depending on their cell of origin: 1) tumors from basal and/or mucous cells; 2) tumors from neurosecretory cells; and 3) tumors from Clara cells. Most carcinomas (88%) arose from basal and/or mucous cells. These were subdivided into epidermoid carcinomas (21%), combined epidermoid and adenocarcinomas (46%), and adenocarcinomas (21%). The criteria for epidermoid differentiation included the presence of tonofilament bundles, poorly developed endoplasmic reticulum and Golgi apparatus, and well-developed desmosomes. The criteria for adeno differentiation included well-developed endoplasmic reticulum and Golgi apparatus, poorly developed desmosomes, the presence of extracellular and/or intracellular alveoli, and/or other evidence of cellular secretion such as secretory granules. In adenocarcinomas with extracellular alveoli, typical junctional complexes were also present at the luminal aspect where the cell apexes bordered the alveolus. With these criteria, combined epidermoid and adenocarcinomas were the most common type of lung carcinoma. We anticipate that the new data will clarify categories such as small cell anaplastic carcinoma and large cell carcinoma of the World Health Organization classification. In addition, the histogenetic classification of lung tumors may be of value in the future in studies of risk factors, prognosis, prevention, and treatment of lung cancer.