Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy
Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy
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DOI：
10.3109/00365521003734158
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发表时间：
2010-11-01
影响因子：
1.9
通讯作者：
Koornstra, Jan J.
中科院分区：
文献类型：
--
作者：
Corporaal, Sietske;Kleibeuker, Jan H.;Koornstra, Jan J.
Objective.大容量的聚乙二醇（PEG）溶液作为结肠镜检查的肠道准备是有效的，但往往耐受性差。比较2 L PEG基溶液与抗坏血酸（PEG + Asc）的组合与4 L PEG基溶液（PEG）。方法.在一项单盲、半随机、前瞻性研究中，350例接受结肠镜检查的患者接受了2 L PEG + Asc或4 L PEG。对于早晨手术，在前一天晚上服用PEG + Asc的总剂量，对于下午结肠镜检查，PEG + Asc作为分次剂量给予。4 L PEG制剂以分次剂量给药。在三个不同的结肠段中，以五点量表对制备的功效进行评分。使用问卷调查评估患者的经历。结果307例患者（149例PEG + Asc，158例PEG）的结果可用。PEG + Asc组的结肠清洁成功率为90.6%，而PEG组为96%（不显著）。在使用PEG + Asc准备的患者中，与下午程序相比，患者在上午接受结肠镜检查时的肠道清洁更差。PEG + Asc组和PEG组的副作用和患者经历相似。结论.低容量PEG +抗坏血酸的疗效和耐受性与高容量PEG溶液相当。如果患者在手术前一天晚上接受全剂量PEG + Asc，与分次剂量相比，清洁结果更差。我们的数据支持PEG + Asc在手术前作为分次剂量给药。
Objective. High volumes of polyethylene glycol (PEG)-based solutions as bowel preparation for colonoscopy are effective, but often poorly tolerated. To compare a 2 l PEG-based solution combined with ascorbic acid (PEG + Asc) with 4 l PEG-based solution (PEG). Methods. In a single blind, quasi-randomized, prospective study, 350 patients undergoing colonoscopy received 2 l of PEG + Asc or 4 l of PEG. For morning procedures, the total dose of PEG + Asc was taken the evening before, for afternoon colonoscopies, PEG + Asc was given as a split dose. The 4 l PEG preparation was given as a split dose. Efficacy of preparation was scored on a five-point scale in three different colon segments. Patients' experiences were evaluated using a questionnaire. Results. From 307 patients (149 PEG + Asc, 158 PEG), results were available. Successful colon cleansing was achieved in 90.6% in the PEG + Asc group compared to 96% in the PEG group (not significant). In patients prepared with PEG + Asc, bowel cleansing was worse when patients underwent colonoscopy in the morning, compared to afternoon procedures. Side-effects and patients' experiences were similar in the PEG + Asc and PEG group. Conclusions. Low-volume PEG + ascorbic acid has comparable efficacy and tolerability as high-volume PEG solution. The cleansing results were worse if patients received the full dose PEG + Asc the evening before the procedure compared to the split dose. Our data support the administration of PEG + Asc as a split dose before the procedure.