Rhythmogenic neuronal networks, emergent leaders, and k-cores.
Rhythmogenic neuronal networks, emergent leaders, and k-cores.
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DOI：
10.1103/physreve.82.051911
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Levine AJ
中科院分区：
文献类型：
--
作者：
Schwab DJ;Bruinsma RF;Feldman JL;Levine AJ
神经元网络的行为源于单个神经元的动态和将它们连接在一起的网络的连通性的结合。我们研究了一个简化的模型，基于费尔德曼和德尔内格罗（FDN）的建议[Nat. Rev. Neurosci. 7,232 (2006)]， preBötzinger复核，一个小的神经元网络，参与控制哺乳动物的呼吸节奏，通过周期性的放电爆发。这种由相同的兴奋性神经元随机连接的网络的动态与均匀连接的网络不同。具体来说，网络连接决定了触发放电的突发领导神经元的身份。当神经元的脱敏由神经元输入信号的数量控制时（正如FDN提出的那样），网络的集体脱敏——成功终止突发所必需的——是由k核神经元集群介导的。
Neuronal network behavior results from a combination of the dynamics of individual neurons and the connectivity of the network that links them together. We study a simplified model, based on the proposal of Feldman and Del Negro (FDN) [Nat. Rev. Neurosci. 7, 232 (2006)], of the preBötzinger Complex, a small neuronal network that participates in the control of the mammalian breathing rhythm through periodic firing bursts. The dynamics of this randomly connected network of identical excitatory neurons differ from those of a uniformly connected one. Specifically, network connectivity determines the identity of emergent leader neurons that trigger the firing bursts. When neuronal desensitization is controlled by the number of input signals to the neurons (as proposed by FDN), the network's collective desensitization—required for successful burst termination—is mediated by k -core clusters of neurons.