A specific B2‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril
A specific B2‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril
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特异性 B2-缓激肽受体拮抗剂 HOE 140 消除雷米普利的抗肥厚作用
DOI：
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发表时间：
1992
影响因子：
7.3
通讯作者：
B. Schölkens
中科院分区：
文献类型：
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作者：
W. Linz;B. Schölkens
为了评估缓动素在血管紧张素转换酶（ACE）抑制剂雷米普利的抗肥厚作用中的作用，我们研究了特异性B2受体拮抗剂HOE 140对雷米普利对主动脉束带大鼠左心室肥厚（LVH）的影响。雷米普利剂量为1mg kg - 1天- 1，连续6周可防止主动脉束带后血压升高和LVH的发生；血浆ACE活性明显受到抑制。低剂量雷米普利（5月1日10 μg kg - 1，连续6周）对血压升高或血浆ACE活性没有影响，但可以预防主动脉束带后LVH。同时给药（500 μ kg - 1 day - 1）可消除高、低剂量雷米普利的抗肥厚作用和高剂量雷米普利的降压作用。目前的数据首次表明，ACE抑制剂对主动脉束带引起的高血压大鼠LVH的有益作用可以被特定的B2受体拮抗剂阻止。
To evaluate the role of bradykinin in the antihypertrophic effect of the angiotensin‐converting enzyme (ACE) inhibitor, ramipril, we investigated the influence of HOE 140, a specific B2‐receptor antagonist, on the effects of ramipril on left ventricular hypertrophy (LVH) in rats with aortic banding. Ramipril at a dose of 1 mg kg−1 day−1 for 6 weeks prevented the increase in blood pressure and development of LVH after aortic banding; plasma ACE activity was significantly inhibited. A lower dose of ramipril (10 μg kg−1 May−1 for 6 weeks) had no effect on the increase in blood pressure or on plasma ACE activity, but prevented LVH after aortic banding. The antihypertrophic effects of the higher and the lower dose ramipril, as well as the antihypertensive action of the higher dose of ramipril were abolished by the coadministration of HOE 140 (500 μg kg−1 day−1). The present data show for the first time that the beneficial effects of an ACE‐inhibitor on LVH in rats with hypertension caused by aortic banding can be prevented by a specific B2‐receptor antagonist.