Updates on the management of gastrointestinal stromal tumors.

Updates on the management of gastrointestinal stromal tumors.
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DOI:
10.1016/j.soc.2011.12.004
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发表时间:
2012-04
影响因子:
1.9
通讯作者:
DeMatteo, Ronald P.
DeMatteo, Ronald P.
中科院分区:
医学4区
文献类型:
--
作者:
Bamboat, Zubin M.;DeMatteo, Ronald P.

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尽管胃肠道间质瘤(GIST)是最常见的胃肠道肉瘤,但它被广泛认为是一种独特的实体只有十多年。酪氨酸激酶抑制剂(TKI)的出现彻底改变了GIST的诊断和治疗。虽然手术仍然是治愈的唯一机会,但包括分子治疗在内的多模式治疗仍在继续发展。GIST的最佳治疗需要仔细的影像学、病理学、内科和外科治疗,强调需要多学科方法。在这篇综述中,我们强调了GIST管理的最新进展。
Despite being the most common sarcoma of the gastrointestinal tract, gastrointestinal stromal tumor (GIST) has only been widely recognized as a unique entity for just over a decade. The advent of tyrosine kinase inhibitors (TKIs) has revolutionized the diagnosis and treatment of GIST. While surgery remains the only chance for cure, multimodal treatment that includes molecular therapy continues to develop. Optimal management of GIST requires careful radiographic, pathologic, medical and surgical care, emphasizing the need for a multidisciplinary approach. In this review we highlight recent developments in the management of GIST.
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