Non-coding RNAs in aortic dissection: From biomarkers to therapeutic targets.
Non-coding RNAs in aortic dissection: From biomarkers to therapeutic targets.
复制标题
主动脉夹层中的非编码 RNA：从生物标志物到治疗靶点
DOI：
10.1111/jcmm.15802
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发表时间：
2020-10
影响因子：
5.3
通讯作者：
Xin H
中科院分区：
文献类型：
--
作者：
Cheng M;Yang Y;Xin H;Li M;Zong T;He X;Yu T;Xin H
主动脉夹层（AD）是主动脉内膜破裂，导致腔内血液进入动脉壁中部。如果没有紧急和适当的治疗，死亡率在48小时内增加到50%。大多数患者表现为急性起病症状，包括突发剧烈疼痛和复杂多变的临床表现，容易误诊。尽管如此，AD的分子机制仍然未知。最近，非编码RNA已成为基因表达的新型调节因子。先前的研究已证明ncRNA可以调节多种心血管疾病;因此，它们作为AD临床生物标志物和新型治疗靶点的潜力引起了广泛的兴趣。迄今为止，一些研究已经报道microRNA在AD进展中起关键作用。此外，已经发现几种长的非编码RNA和环状RNA在AD样品中差异表达，表明它们在血管生理学和疾病中的潜在作用。在这篇综述中，我们讨论了ncRNA在AD病理生理学中的功能，并强调了它们作为AD生物标志物和治疗靶点的潜力。同时介绍了以往用于AD研究的动物模型，以及小鼠和大鼠AD模型的具体构建方法。
Aortic dissection (AD) is the rupture of the aortic intima, causing the blood in the cavity to enter the middle of the arterial wall. Without urgent and proper treatment, the mortality rate increases to 50% within 48 hours. Most patients present with acute onset of symptoms, including sudden severe pain and complex and variable clinical manifestations, which can be easily misdiagnosed. Despite this, the molecular mechanisms underlying AD are still unknown. Recently, non‐coding RNAs have emerged as novel regulators of gene expression. Previous studies have proven that ncRNAs can regulate several cardiovascular diseases; therefore, their potential as clinical biomarkers and novel therapeutic targets for AD has aroused widespread interest. To date, several studies have reported that microRNAs are crucially involved in AD progression. Additionally, several long non‐coding RNAs and circular RNAs have been found to be differentially expressed in AD samples, suggesting their potential roles in vascular physiology and disease. In this review, we discuss the functions of ncRNAs in AD pathophysiology and highlight their potential as biomarkers and therapeutic targets for AD. Meanwhile, we present the animal models previously used for AD research, as well as the specific methods for constructing mouse or rat AD models.
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影响因子：
21.3
作者：
Hergenreider, Eduard;Heydt, Susanne;Dimmeler, Stefanie
通讯作者：
Dimmeler, Stefanie
DOI：
10.1093/ejcts/ezw245
发表时间：
2017-01
期刊：
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
影响因子：
--
作者：
Harling L;Lambert J;Ashrafian H;Darzi A;Gooderham NJ;Athanasiou T
通讯作者：
Athanasiou T
影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
DOI：
10.1042/cs20120479
发表时间：
2013-08
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Chiao CW;da Silva-Santos JE;Giachini FR;Tostes RC;Su MJ;Webb RC
通讯作者：
Webb RC
影响因子：
39.3
作者：
Erbel, Raimund;Aboyans, Victor;Vrints, Christiaan J. M.
通讯作者：
Vrints, Christiaan J. M.