High-resolution magnetic resonance spectroscopy in unstable fields via intermolecular zero-quantum coherences.
High-resolution magnetic resonance spectroscopy in unstable fields via intermolecular zero-quantum coherences.
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DOI：
10.1039/b920180g
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发表时间：
2010-06
期刊：
影响因子：
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通讯作者：
Meijin Lin;Xi Chen;S. Cai;Zhong Chen
中科院分区：
文献类型：
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作者：
Meijin Lin;Xi Chen;S. Cai;Zhong Chen
分子间零量子相干（izqc）已被用于在非均匀和/或不稳定场下获得高分辨率核磁共振（NMR）质子谱。在本文中，我们证明了尽管iZQC对B(0)变化不敏感，但不稳定场对可观测到的单量子相干信号的影响会在高分辨率iZQC光谱中引起强烈的t(1)噪声。提出了短时间采集（STA）和相位谱方案来抑制体内iZQC磁共振波谱（MRS）在时间B(0)变化下的噪声。通过Z0线圈电流振荡产生的B(0)变化和场梯度存在下体素位置变化的局部光谱研究，模拟了生理运动存在下MRS的场条件，验证了这些方案的可行性。相位方案不仅提高了信噪比，而且进一步将线宽减小了一半。
Intermolecular zero-quantum coherences (iZQCs) have been utilized to achieve high-resolution nuclear magnetic resonance (NMR) proton spectra under inhomogeneous and/or unstable fields. In this paper, we demonstrated that despite the insensitivity of iZQCs to B(0) variations, the influence of unstable fields on the observable single-quantum coherence signals causes strong t(1) noises in the high-resolution iZQC spectra. Short-time acquisition (STA) and phase spectrum schemes were proposed for noise suppression in in vivo iZQC magnetic resonance spectroscopy (MRS) under temporal B(0) variations. The feasibility of these schemes were verified by localized spectroscopic studies under B(0) variations generated by the Z0 coil current oscillations and by voxel position variations in the presence of field gradients, which simulate the field conditions of MRS in the presence of physiological motions. The phase scheme not only improves the signal-to-noise ratio but also further reduces the linewidth by half.