Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3
Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3
复制标题
单次口服高剂量维生素 D3 后的药代动力学和人口因素对血液 25(OH)D3 水平的影响
DOI：
10.1038/aps.2016.82
复制
发表时间：
2016-11-01
影响因子：
8.2
通讯作者：
Wang, Hui
中科院分区：
文献类型：
--
作者：
Chen, Pei-zhan;Li, Mian;Wang, Hui
目的：研究维生素 D 缺乏状态的中国年轻人群单次高剂量干预后可能影响维生素 D3 药代动力学的生物学后果和人口统计学因素。方法：总共 28 名维生素 D 缺乏状态的年轻受试者（25 至 35 岁）[血清 25(OH) D = 30 ng/mL]，为期 56 d。干预后，体重和基线 25(OH) D3 水平与循环 25(OH) D3 水平显着相关。未观察到不良事件，血清钙、肌酐、血糖、甲状旁腺激素、维生素 D 结合蛋白或尿钙/肌酐比值也没有持续显着变化。然而，维生素 D3 干预后，磷含量显着增加。试验结束时总胆固醇和甘油三酯水平有所下降。结论：干预后维生素 D 的药代动力学受到基线 25(OH) D3 水平和受试者体重的影响。结果表明，单次高口服维生素 D3 干预对于改善维生素 D 缺乏的中国年轻人的维生素 D 状况是安全有效的。
Aim: To examine the biological consequences and demographic factors that might affect the pharmacokinetics of vitamin D3 after a single high dose intervention in a young Chinese population with vitamin D insufficiency status.Methods: A total of 28 young subjects (25 to 35 years old) with vitamin D insufficiency status [serum 25(OH) D = 30 ng/mL) for 56 d. After the intervention, body weight and baseline 25(OH) D3 levels were significantly correlated with circulating 25(OH) D3 levels. No adverse events and no consistently significant changes in serum calcium, creatinine, glucose, parathyroid hormone, vitamin D binding protein, or the urinary calcium/creatinine ratio were observed. However, there was a significant increase in phosphorus after the vitamin D3 intervention. Total cholesterol and triglyceride levels were decreased at the end of the trial.Conclusion: The pharmacokinetics of vitamin D after intervention were influenced by baseline 25(OH) D3 levels and the body weight of the subjects. The results suggest that a single high oral vitamin D3 intervention is safe and efficient for improving the vitamin D status of young Chinese people with vitamin D insufficiency.