Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis.
Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis.
复制标题
使用 GRASP MRI 同时评估肝纤维化的灌注和形态。
DOI：
10.1007/s00330-021-08087-2
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发表时间：
2022
影响因子：
5.9
通讯作者：
Yoon JH
中科院分区：
文献类型：
--
作者：
Yoon JH
ObjectivesTo确定如果黄金角放射状稀疏平行（GRASP）动态对比增强（DCE）-MRI允许同时评价灌注和肝纤维化的形态学。MethodsParticipants谁被安排肝活检或切除入组（NCT 02480972）。图像重建在12秒的时间分辨率的形态评估和在3.3秒的时间分辨率的定量评价。以四分制评估形态图像的图像质量，并记录肝脏观察的肝脏成像报告和数据系统评分。比较了不同纤维化阶段的DCE-MRI定量参数之间的差异，并为肝细胞癌（HCC）与不同LR features.ResultsDCE-MRI的64名参与者（男性= 48）进行了分析。在整个检查过程中，总体图像质量始终保持在3.5 ± 0.4至3.7 ± 0.4之间。F2-F3参与者的门静脉血流量显著降低（n = 18，175 ± 110 mL/100 mL/min）和F4（n = 12，98 ± 47 mL/100 mL/min）与F0-F1参与者（n = 34，283 ± 178 mL/100 mL/min，所有p< 0.05）相比。在F4参与者中，动脉分数和细胞外容积显著高于F0-F1和F2-F3参与者（p< 0.05）。与显示非LR-M特征的HCC（n = 16）相比，具有LR-M的HCC（n = 5）具有显著延长的平均通过时间和较低的动脉血流量（p< 0.05）。在不同的肝纤维化阶段，MRI衍生的门静脉血流量之间存在显著差异。KeyPointsA单一MRI检查能够提供具有足够空间分辨率的图像用于解剖学评估，以及具有高时间分辨率的图像用于药代动力学建模。门静脉血流量在临床显著的肝纤维化中显著降低，并且在肝硬化中平均通过时间和细胞外体积增加，与无肝纤维化或轻度肝纤维化组相比，不同LR特征的HCC表现出不同的DCE-MRI定量参数：LR-M特征的HCC表现出较长的平均通过时间和较低的动脉血流。
ObjectivesTo determine if golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced (DCE)-MRI allows simultaneous evaluation of perfusion and morphology in liver fibrosis.MethodsParticipants who were scheduled for liver biopsy or resection were enrolled (NCT02480972). Images were reconstructed at 12-s temporal resolution for morphologic assessment and at 3.3-s temporal resolution for quantitative evaluation. The image quality of the morphologic images was assessed on a four-point scale, and the Liver Imaging Reporting and Data System score was recorded for hepatic observations. Comparisons were made between quantitative parameters of DCE-MRI for the different fibrosis stages, and for hepatocellular carcinoma (HCCs) with different LR features.ResultsDCE-MRI of 64 participants (male = 48) were analyzed. The overall image quality consistently stood at 3.5 ± 0.4 to 3.7 ± 0.4 throughout the exam. Portal blood flow significantly decreased in participants with F2–F3 (n = 18, 175 ± 110 mL/100 mL/min) and F4 (n = 12, 98 ± 47 mL/100 mL/min) compared with those in participants with F0–F1 (n = 34, 283 ± 178 mL/100 mL/min,p< 0.05 for all). In participants with F4, the arterial fraction and extracellular volume were significantly higher than those in participants with F0–F1 and F2–F3 (p< 0.05). Compared with HCCs showing non-LR-M features (n = 16), HCCs with LR-M (n = 5) had a significantly prolonged mean transit time and lower arterial blood flow (p< 0.05).ConclusionsLiver MRI using GRASP obtains both sufficient spatial resolution for confident diagnosis and high temporal resolution for pharmacokinetic modeling. Significant differences were found between the MRI-derived portal blood flow at different hepatic fibrosis stages.Key PointsA single MRI examination is able to provide both images with sufficient spatial resolution for anatomic evaluation and those with high temporal resolution for pharmacokinetic modeling.Portal blood flow was significantly lower in clinically significant hepatic fibrosis and mean transit time and extracellular volume increased in cirrhosis, compared with those in no or mild hepatic fibrosis.HCCs with different LR features showed different quantitative parameters of DCE-MRI: longer mean transit time and lower arterial flow were observed in HCCs with LR-M features.