Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.
Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.
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DOI：
10.1016/j.biopsych.2020.02.004
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发表时间：
2020-09-01
影响因子：
10.6
通讯作者：
Iñiguez SD
中科院分区：
文献类型：
--
作者：
Warren BL;Mazei-Robison MS;Robison AJ;Iñiguez SD
慢性社交挫败压力（CSDS）模型有助于我们理解与情感相关疾病（包括重度抑郁症（MDD））相关的神经生物学。然而，经典的 CSDS 程序因其仅适用于成年雄性啮齿动物而受到限制。我们最近开发了一种新颖的替代社会失败压力（VDS）程序，其中一只小鼠在相邻隔间的安全处目睹了同种动物的身体失败。这只见证小鼠表现出与身体上经历社交失败压力的小鼠相似的行为表型，模拟了 MDD 的多个方面。重要的是，这种新程序允许研究人员对雄性或雌性以及幼年小鼠进行 VDS——这些小鼠通常被排除在经典的社交失败实验之外。在这里，我们讨论使用该程序取得的一些最新进展，以及它的应用如何提供一种新的临床前方法来研究心理压力诱发表型的神经生物学。
The chronic social defeat stress (CSDS) model has been instrumental in shaping our understanding of neurobiology relevant to affect-related illnesses, including major depressive disorder (MDD). However, the classic CSDS procedure is limited by its exclusive application to adult male rodents. We have recently developed a novel vicarious social defeat stress (VDS) procedure wherein one mouse witnesses the physical defeat bout of a conspecific from the safety of an adjacent compartment. This witness mouse develops a similar behavioral phenotype to that of the mouse that physically experiences social defeat stress, modeling multiple aspects of MDD. Importantly, this new procedure allows researchers to perform VDS in males or females, and in juvenile mice – which typically are excluded from classic social defeat experiments. Here we discuss several recent advances made using this procedure, and how its application provides a new preclinical approach to study the neurobiology of psychological stress-induced phenotypes.
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影响因子：
2.7
作者：
Fan Jianhua;Wei Wei;Wang Shao-Hui
通讯作者：
Wang Shao-Hui
影响因子：
11
作者：
Fox ME;Chandra R;Menken MS;Larkin EJ;Nam H;Engeln M;Francis TC;Lobo MK
通讯作者：
Lobo MK
影响因子：
5.3
作者：
Boyson, Christopher O.;Holly, Elizabeth N.;Miczek, Klaus A.
通讯作者：
Miczek, Klaus A.
DOI：
10.1093/ijnp/pyw089
发表时间：
2017-03-01
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Dong C;Zhang JC;Yao W;Ren Q;Ma M;Yang C;Chaki S;Hashimoto K
通讯作者：
Hashimoto K
大脑奖励回路中的中脑边缘多巴胺神经元介导对社交失败和抗抑郁作用的敏感性
DOI：
10.1523/jneurosci.3177-10.2010
发表时间：
2010-12-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cao JL;Covington HE 3rd;Friedman AK;Wilkinson MB;Walsh JJ;Cooper DC;Nestler EJ;Han MH
通讯作者：
Han MH