Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.
Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.
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DOI：
10.4103/1673-5374.143410
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发表时间：
2014-10-01
影响因子：
6.1
通讯作者：
Sullivan AM
中科院分区：
文献类型：
--
作者：
Hegarty SV;O'Keeffe GW;Sullivan AM
神经保护和神经再生是治疗无法治愈且广泛存在的帕金森病的两种最有前途的疾病改善疗法。在帕金森氏病中，黑质纹状体多巴胺能神经元的进行性变性导致使人衰弱的运动症状。神经营养因子在特定神经元群体的发育、存活和维持中起重要的调节作用。这些因素有可能减缓，停止或逆转帕金森病中黑质纹状体多巴胺能神经元的损失。在这方面，已经研究了几种神经营养因子。这篇综述文章讨论了三种多巴胺能神经营养因子的神经发育作用和治疗潜力：胶质细胞源性神经营养因子，neurturin和生长/分化因子5。
Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.