COMPARISON OF NEUROLOGIC CHANGES IN SUCCESSFULLY AGING PERSONS VS THE TOTAL AGING POPULATION
COMPARISON OF NEUROLOGIC CHANGES IN SUCCESSFULLY AGING PERSONS VS THE TOTAL AGING POPULATION
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DOI：
10.1001/archneur.1994.00540180051013
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发表时间：
1994-06-01
影响因子：
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通讯作者：
ALBERT, M
中科院分区：
文献类型：
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作者：
ODENHEIMER, G;FUNKENSTEIN, HH;ALBERT, M
目的：确定一般人群中神经系统功能与年龄相关的变化。设计：对参与者进行神经系统检查，以便能够计算出人口中出现每项异常发现的老年人的比例，以及有每项发现但没有可能产生神经系统异常（例如中风和糖尿病）的医学和神经系统疾病证据的人群的比例。设置：从社区居住人群中选择个体。参与者：467 名老年人的分层随机样本评估对象为 65 岁及以上。结果：随着年龄的增长，许多神经系统异常越来越常见，并且存在于很大一部分老年人口中。然而，与疾病无关的神经系统异常发现的患病率要低得多，通常为总患病率的一半到三分之一。此外，随着年龄的增长，不归因于重大疾病的异常神经系统发现的患病率在不同的测量中差异很大。结论：原始反射和步态测量在多个测量领域中显示出随年龄的统计显着增加，表明选择性的与年龄相关的脆弱性。
Objective: To determine age-related changes in neurologic function in the general population.Design: To administer a neurologic examination to participants in such a way that it is possible to calculate the proportion of elderly persons in the population with each abnormal finding and the proportion of persons with each finding but without evidence of the medical and neurologic diseases likely to produce neurologic abnormalities (eg, stroke and diabetes).Setting: Individuals were selected from a community-dwelling population.Participants: A stratified random sample of 467 persons aged 65 years and older were evaluated.Results: Many neurologic abnormalities are increasingly common with advancing age and are present in a substantial portion of the elderly population. The prevalence of abnormal neurologic findings not attributable to disease, however, is substantially lower, typically one half to one third the total prevalence. Moreover, the increase with age in the prevalence of abnormal neurologic findings not attributable to major disease varies substantially among the different measures.Conclusions: Primitive reflexes and measures of gait show statistically significant increases with age in multiple measurement domains, suggesting a selective age-related vulnerability.