Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation
Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation
复制标题
DOI：
10.3892/or.2017.5803
复制
发表时间：
2017-09-01
期刊：
影响因子：
4.2
通讯作者：
Bermano, Giovanna
中科院分区：
文献类型：
--
作者：
Barron, Gemma A.;Goua, Marie;Bermano, Giovanna
本研究利用一种通用的体外内皮细胞/成纤维细胞共培养系统，通过比较乳腺癌患者和年龄匹配的对照组的血浆容量，研究血管生成与乳腺癌之间的关系，在体外影响小管形成和调节血管生成，并确定可能起作用的血浆循环因素。来自乳腺癌患者(n=8)的血浆(共培养建立后第7天加入)显著增加了57%的小管形成(P
The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matched controls, to influence tubule formation and modulate angiogenesis in vitro, and to identify plasma circulating factors which might be responsible. Plasma from women with breast cancer (n=8) (added on day 7 after co-culture establishment) significantly increased tubule formation by 57% (P