In-beam PET imaging for the control of heavy-ion tumour therapy
In-beam PET imaging for the control of heavy-ion tumour therapy
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DOI：
10.1109/nssmic.1996.591573
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发表时间：
1996-11
期刊：
影响因子：
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通讯作者：
J. Pawelke;Wolfgang Enghardt;T. Haberer;B. Hasch;Rainer Hinz;Michael Krämer;K. Lauckner;M. Sobiella
中科院分区：
文献类型：
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作者：
J. Pawelke;Wolfgang Enghardt;T. Haberer;B. Hasch;Rainer Hinz;Michael Krämer;K. Lauckner;M. Sobiella
本文介绍了一种利用正电子发射断层扫描技术对重离子治疗肿瘤进行原位控制的方法。该方法建立在测量辐照过程中核碎裂产生的/spl β//sup +/-发射体的动态空间分布以及/spl β//sup +/-放射性空间分布与剂量之间的关系的基础上。为了研究这种关系，并从测量的/spl β//sup +/-活性分布推导出剂量分布，使用了模型计算的框架。幻影实验与/sup 12/C离子束的结果，展示了良好的协议之间的实验和模拟以及治疗计划验证和束流监测的可能性和限制。
A method for the in-situ control of the heavy-ion tumour therapy by means of positron emission tomography is introduced. This method is founded on the measurement of the dynamic spatial distribution of /spl beta//sup +/-emitters generated by nuclear fragmentation during the irradiation and the relationship between the spatial distributions of the /spl beta//sup +/-radioactivity and the dose. In order to study this relationship and to arrive at deducing the dose distribution from the measured /spl beta//sup +/-activity distribution a framework of model calculations is used. Results of phantom experiments with /sup 12/C ion beams are presented, demonstrating the good agreement between experiment and simulation as well as the possibilities and limits of treatment plan verification and beam monitoring.