DECLINING SERUM TOTAL CHOLESTEROL LEVELS AMONG UNITED-STATES ADULTS - THE NATIONAL-HEALTH AND NUTRITION EXAMINATION SURVEYS
DECLINING SERUM TOTAL CHOLESTEROL LEVELS AMONG UNITED-STATES ADULTS - THE NATIONAL-HEALTH AND NUTRITION EXAMINATION SURVEYS
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DOI：
10.1001/jama.269.23.3002
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发表时间：
1993-06-16
影响因子：
120.7
通讯作者：
CLEEMAN, JI
中科院分区：
文献类型：
--
作者：
JOHNSON, CL;RIFKIND, BM;CLEEMAN, JI
目标：-研究美国成年人血清总胆固醇水平的长期趋势。设计-具有全国代表性的横断面调查，既有面谈，也有包括测量血脂水平的体检。设置/参与者。-在1960年至1962年、1971年至1974年、1976年至1980年和1988年至1991年的四次单独的全国性调查中，分别对6000至13000名年龄在20岁至74岁之间的成年人进行了检查。结果：美国20岁至74岁成年人的平均血清总胆固醇水平在1960年至1991年期间持续下降。超过一半的下降发生在1976年至1991年期间。这一下降发生在整个血清胆固醇水平分布和所有年龄性别组中。高密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平没有变化，这表明总胆固醇水平的下降是由于低密度脂蛋白胆固醇水平的下降。结论--这些结果证明美国成年人的血清胆固醇水平持续大幅下降。他们表示，旨在降低胆固醇水平的公共卫生计划被证明是成功的。观察到的血清胆固醇水平的下降趋势与冠心病死亡率的持续下降相吻合。这些观察表明，健康人2000年的目标是将美国成年人的平均血清胆固醇水平降低到不超过200毫克/分升(5.17摩尔/L)是可以实现的。
Objective.-To examine the secular trend in serum total cholesterol levels of the US adult population.Design.-Nationally representative cross-sectional surveys with both an in-person interview and a medical examination that included the measurement of blood lipid levels.Setting/Participants.-Between 6000 and 13 000 adults aged 20 through 74 years examined in each of four separate national surveys during 1960 through 1962, 1971 through 1974, 1976 through 1980, and 1988 through 1991.Results.-Mean serum total cholesterol levels in US adults aged 20 through 74 years have consistently declined over the time period 1960 through 1991. More than half of the decline occurred during the time period 1976 through 1991. This decline occurred across the entire distribution of serum cholesterol levels and in all age-sex groups. High-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels have not changed, suggesting that the decline in total cholesterol levels is due to a decline in low-density lipoprotein cholesterol levels.Conclusions.-These results document a continuing and substantial decline in serum cholesterol levels among US adults. They suggest that public health programs, designed to reduce cholesterol levels, are proving successful. The observed downward trend in serum cholesterol levels has coincided with a continuing decline in coronary heart disease mortality. These observations suggest that the Healthy People 2000 goal of reducing the mean serum cholesterol level of US adults to no more than 200 mg/dL (5.17 mmol/L) is attainable.