A Simple Noninvasive Index Can Predict Hepatocellular Carcinoma in Patients with Chronic Hepatitis B.
A Simple Noninvasive Index Can Predict Hepatocellular Carcinoma in Patients with Chronic Hepatitis B.
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一个简单的无创指标可以预测慢性乙型肝炎患者的肝细胞癌
DOI：
10.1038/s41598-017-09358-z
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发表时间：
2017-08-21
影响因子：
4.6
通讯作者：
Qin C
中科院分区：
文献类型：
--
作者：
Zhu L;Li T;Ma X;Qiu Y;Ma X;Lin Y;Han L;Qin C
筛查慢性B型肝炎（CH B）患者可能发生的肝细胞癌（HCC）对于风险预测和早期治疗至关重要。这项研究报告了一种新的模型，包括常规实验室变量预测肝癌从慢性乙型肝炎。对463名参与者进行了回顾性研究。构建甲胎蛋白（AFP）、血小板和丙氨酸氨基转移酶（ALT）比值（APAR）以区分HCC与CHB或非癌症，其在训练集中的受试者工作特征曲线（AUC）下的面积分别为0.815和0.868，在验证集中分别为0.831和0.861。在AFP低或正常（<100 ng/mL）的参与者中，通过AUC测量的APAR预测HCC与CHB或非癌症的诊断效力分别为0.817和0.809，并且在0.47的截止值时，灵敏度，特异性，阳性预测值（PPV）和阴性预测值（NPV）分别为89%，60%，67%和86%。对于AFP正常（<20 ng/mL）的受试者，APAR的AUC为0.839和0.746，临界值为0.36，灵敏度、特异性、PPV和NPV分别为88%、69%、71%和87%。总之，APAR是一种有效的肝癌筛查模型，特别是在那些血清AFP水平低甚至正常的人中。
Screening for possible development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) is essential for risk prediction and early therapy. This study reported a novel model comprised of routine laboratory variables for predicting HCC from CHB. A retrospective study was performed among 463 participants. alpha-fetoprotein (AFP), platelet and alanine aminotransferase (ALT) ratio (APAR) was constructed to differentiate HCC from CHB or non-cancer with area under the receiver operating characteristic curves (AUC) of 0.815 and 0.868 in the training set, 0.831 and 0.861 in the validation set, respectively. In participants with low or normal AFP (<100 ng/mL), the diagnostic efficacy of APAR measured by AUC were 0.817 and 0.809 for predicting HCC from CHB or non-cancer, and at a cutoff of 0.47, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 89%, 60%, 67% and 86%, respectively. For participants with normal AFP (<20 ng/mL), the AUC of APAR were 0.839 and 0.746 accompanied by a cutoff of 0.36 with sensitivity, specificity, PPV, and NPV of 88%, 69%, 71%, and 87%, respectively. In conclusion, APAR is an effective model for HCC screening especially in those with low even normal serum AFP levels.
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影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
影响因子：
6.4
作者：
Schmidt B;Wei L;DePeralta DK;Hoshida Y;Tan PS;Sun X;Sventek JP;Lanuti M;Tanabe KK;Fuchs BC
通讯作者：
Fuchs BC
影响因子：
3.8
作者：
Ji F;Liang Y;Fu SJ;Guo ZY;Shu M;Shen SL;Li SQ;Peng BG;Liang LJ;Hua YP
通讯作者：
Hua YP
治疗前中性粒细胞-淋巴细胞比率：肝细胞癌患者生存的独立预测因子。
影响因子：
1.6
作者：
Gao F;Li X;Geng M;Ye X;Liu H;Liu Y;Wan G;Wang X
通讯作者：
Wang X
影响因子：
8
作者：
Kim, Seok-Hwan;Moon, Deok-Bog;Lee, Sung-Gyu
通讯作者：
Lee, Sung-Gyu