Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample.
Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample.
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DOI：
10.1177/0022146515582100
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发表时间：
2015-06
影响因子：
5
通讯作者：
Blackburn EH
中科院分区：
文献类型：
--
作者：
Geronimus AT;Pearson JA;Linnenbringer E;Schulz AJ;Reyes AG;Epel ES;Lin J;Blackburn EH
贫困城区的居民患有与过早衰老相关的疾病，且死亡率过高。通过社会研究人员和细胞生物学家合作开展的基于社区的参与式研究方法，我们从底特律三个街区分层、多阶段概率抽样的239名黑人、白人或墨西哥裔成年人中收集了一组独特的数据。我们抽取静脉血并测量了端粒长度（TL），这是一种由压力介导的生物衰老指标，并将受访者的端粒长度与其社区调查的回答相关联。我们将端粒长度对社会经济、社会心理、社区和行为压力因素进行回归分析，假设并发现贫困与种族/族裔群体之间存在相互作用。贫困白人的端粒长度比非贫困白人短；贫困黑人和非贫困黑人的端粒长度相当；贫困墨西哥裔的端粒长度比非贫困墨西哥裔长。研究结果表明，未观测到的异质性偏差是对按种族/族裔划分的端粒长度差异估计有效性的一个重要威胁。它们表明社会身份对健康的影响是有条件的，是源于结构的生物心理社会过程的产物。
Residents of distressed urban areas suffer early aging-related disease and excess mortality. Using a community-based participatory research approach in a collaboration between social researchers and cellular biologists, we collected a unique data set of 239 black, white, or Mexican adults from a stratified, multi-stage probability sample of three Detroit neighborhoods. We drew venous blood and measured Telomere Length (TL), an indicator of stress-mediated biological aging, linking respondents’ TL to their community survey responses. We regressed TL on socioeconomic, psychosocial, neighborhood, and behavioral stressors, hypothesizing and finding an interaction between poverty and racial/ethnic group. Poor whites had shorter TL than nonpoor whites; poor and nonpoor blacks had equivalent TL; poor Mexicans had longer TL than nonpoor Mexicans. Findings suggest unobserved heterogeneity bias is an important threat to the validity of estimates of TL differences by race/ethnicity. They point to health impacts of social identity as contingent, the products of structurally-rooted biopsychosocial processes.