Cancer and the bromodomains of BAF180
Cancer and the bromodomains of BAF180
复制标题
DOI：
10.1042/bst20110754
复制
发表时间：
2012-04-01
影响因子：
3.9
通讯作者：
Downs, Jessica A.
中科院分区：
文献类型：
--
作者：
Brownlee, Peter M.;Chambers, Anna L.;Downs, Jessica A.
染色质重塑复合物改变染色质的结构，并在所有DNA模板的活动，包括基因表达和DNA修复的调节中发挥核心作用。PBAF（多溴/Brg 1相关因子）或SWI/SNF-B重塑复合物（包括BAF 180）亚基的突变通常与癌症相关。在BAF 180中存在六个潜在的乙酰基-赖氨酸结合BD（溴结构域），其可发挥作用以将PBAF复合物靶向DNA修复的启动子或位点。在本综述中，我们讨论了目前已知的BAF 180的BD及其在癌症中的潜在意义。
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.