Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes
Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes
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可变形膜管上曲率诱导蛋白的兴奋反应扩散波
DOI：
10.1103/physreve.106.024403
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发表时间：
2022
影响因子：
2.4
通讯作者：
N. Tamemoto and H. Noguchi
中科院分区：
文献类型：
--
作者：
樹神克明、山内宏樹;本田孝志、社本真一;井川直樹、池田一貴; 大友季哉;N. Tamemoto and H. Noguchi
活细胞利用可兴奋的反应扩散波来实现内部细胞功能，其中经常涉及曲率诱导蛋白。然而，它们的机械化学耦合的作用尚不清楚。在这里，我们使用改进的 FitzHugh-Nagumo 模型对管状膜进行粗粒度模拟，报告了由曲率诱导蛋白的可兴奋反应扩散波引起的膜变形以及由于变形引起的波的交替。蛋白质传播波使管状膜变形，大的变形会引起出芽波和擦除波。波速和形状由膜变形和曲率诱导蛋白的空间分布的组合决定。根据条件，波也会在方位角方向上波动。旋转对称波使管局部变形为对称形状，但平均保持直线形状。我们的模拟方法可以应用于其他化学反应模型并用于研究各种生物膜现象。
Living cells employ excitable reaction-diffusion waves for internal cellular functions, in which curvature-inducing proteins are often involved. However, the role of their mechanochemical coupling is not well understood. Here, we report the membrane deformation induced by the excitable reaction-diffusion waves of curvature-inducing proteins and the alternation in the waves due to the deformation, using a coarse-grained simulation of tubular membranes with a modified FitzHugh-Nagumo model. Protein-propagating waves deform tubular membranes and large deformations induce budding and erase waves. The wave speed and shape are determined by a combination of membrane deformation and spatial distribution of the curvature-inducing protein. Waves are also undulated in the azimuthal direction depending on the condition. Rotationally symmetric waves locally deform the tubes into a symmetric shape but maintain a straight shape on average. Our simulation method can be applied to other chemical reaction models and used to investigate various biomembrane phenomena.