Circulating IgG antibodies against factors IX and VIII in multiple sclerosis.
Circulating IgG antibodies against factors IX and VIII in multiple sclerosis.
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多发性硬化症中针对 IX 因子和 VIII 因子的循环 IgG 抗体。
DOI：
10.1159/000207993
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发表时间：
1976
影响因子：
2.4
通讯作者：
L. Wright
中科院分区：
文献类型：
--
作者：
J. Moake;C. Kent;L. D. Meta;L. Wright
一名64岁的多发性硬化症患者出现循环抗凝剂。通过33%硫酸铵沉淀和DEAE-52纤维素柱层析从患者血清中分离出三种免疫球蛋白组分（I = IgG; II =IgG+伊加; III = IgM）。组分I（IgG）和II（IgG+伊加）在孵育时具有因子VIII抑制活性。此外，组分I（IgG）具有不需要孵育的立即抗IX活性。吸收研究将VIII抑制剂表征为组分I中的IgG-γ和组分II中的IgG-γ + IgG-λ。与动力学上不同的IgG抗VIII抗体相关的立即反应性IgG抗IX抗体先前尚未描述。
A 64-year-old man with multiple sclerosis developed a circulating anticoagulant. Three immunoglobulin fractions (I = IgG; II =IgG+IgA; III = IgM) were separated from patient serum by 33-percent ammonium sulfate precipitation and DEAE-52 cellulose column chromatography. Fractions I (IgG) and II (IgG+IgA) had factor VIII inhibitory activity on incubation. Fraction I (IgG) possessed, in addition, immediate anti-IX activity which did not require incubation. Absorption studies characterized the VIII inhibitors as IgG-gamma in fraction I and IgG-gamma+IgG-lambda in fraction II. Immediately reactive IgG anti-IX antibodies associated with kinetically distinct IgG anti-VIII antibodies have not been described previously.