Retromer: A Master Conductor of Endosome Sorting
Retromer: A Master Conductor of Endosome Sorting
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DOI：
10.1101/cshperspect.a016774
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发表时间：
2014-02-01
影响因子：
7.2
通讯作者：
Cullen, Peter J.
中科院分区：
文献类型：
--
作者：
Burd, Christopher;Cullen, Peter J.
内体网络包括膜隔室的互连网络，其主要功能是接收、解离和分选源自质膜和生物合成途径的货物。细胞生物学的一个主要挑战是实现对该网络如何运作的彻底分子描述，以及在这样做的过程中，缺陷如何导致人类疾病的病因学和病理学。我们讨论了越来越多的证据表明，涉及一个古老的进化保守的复杂的，称为“retromer”，作为一个主指挥复杂的编排内体网络内的多个货物分拣事件。
The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the biosynthetic pathway. A major challenge in cell biology is to achieve a thorough molecular description of how this network operates, and in so doing, how defects contribute to the etiology and pathology of human disease. We discuss the increasing body of evidence that implicates an ancient evolutionary conserved complex, termed "retromer," as a master conductor in the complex orchestration of multiple cargo-sorting events within the endosomal network.