The relationship between psychological risk attributes and the metabolic syndrome in healthy women:: Antecedent or consequence?
The relationship between psychological risk attributes and the metabolic syndrome in healthy women:: Antecedent or consequence?
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DOI：
10.1053/meta.2002.36301
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发表时间：
2002-12-01
影响因子：
9.8
通讯作者：
Kuller, LH
中科院分区：
文献类型：
--
作者：
Räikkönen, K;Matthews, KA;Kuller, LH
代谢综合征是妇女主要慢性疾病的一个重要危险因素。在先前的流行病学研究中，该综合征的一个关键组成部分，中枢性肥胖，与与冠状动脉疾病相关的心理危险因素相关。我们评估了心理危险因素是否能预测代谢综合征以及代谢综合征是否能预测心理困扰。一项以人群为基础的队列研究对425名中年、绝经前、围绝经期和绝经后妇女进行了平均7.4年的随访。心理危险因素，包括抑郁、焦虑、紧张、当前感知压力和愤怒，以及代谢综合征的生物成分，包括葡萄糖、甘油三酯、高密度脂蛋白(HDL)-胆固醇、腰围和血压（BP），在基线和绝经后1至8年的检查中进行测量。根据国家心脏、肺和血液研究所（NHLBI）的代谢综合征标准对妇女进行分类。在基线时表现出高水平的抑郁、紧张和愤怒，并且在随访期间愤怒程度增加的妇女在随访期间发生代谢综合征的风险增加，P < 0.04。基线代谢综合征反过来预测7.4年后愤怒和焦虑的增加，P < 0.001。心理危险因素影响代谢综合征的发展。愤怒和代谢综合症之间的联系是相互的。减少心理困扰水平可以预防女性代谢综合征的发展。版权所有，爱思唯尔科学（美国）。版权所有。
The metabolic syndrome is an important risk factor for major chronic diseases in women. A key component of the syndrome, central adiposity, is correlated with psychological risk factors associated with coronary artery disease in prior epidemiological studies. We evaluated if psychological risk factors predicted the metabolic syndrome and if the metabolic syndrome predicted psychological distress. A population-based cohort of 425 women who were middle-aged, and pre-, peri-, and postmenopausal was followed for an average 7.4 years. Psychological risk factors, including depression, anxiety, tension, current perceived stress, and anger, and biological components of the metabolic syndrome, including glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, waist circumference, and blood pressure (BP) were measured at baseline and at examinations 1 to 8 years postmenopause. Women were classified according to the National Heart, Lung, and Blood Institute (NHLBI) criteria for metabolic syndrome. Women who exhibited high levels of depression, tension, and anger at baseline, and increased in anger during the follow-up had elevated risk for developing the metabolic syndrome during follow-up, P < .04. The metabolic syndrome at baseline, in turn, predicted increasing anger and anxiety 7.4 years later, P < .001. Psychological risk factors affect the development of the metabolic syndrome. The association between anger and the metabolic syndrome is reciprocal. Reduction in the level of psychological distress may prevent the development of the metabolic syndrome in women. Copyright 2002, Elsevier Science (USA). All rights reserved.