Inflammatory Markers in Anorexia Nervosa: An Exploratory Study
Inflammatory Markers in Anorexia Nervosa: An Exploratory Study
复制标题
DOI：
10.3390/nu10111573
复制
发表时间：
2018-11-01
期刊：
影响因子：
5.9
通讯作者：
Himmerich, Hubertus
中科院分区：
文献类型：
--
作者：
Dalton, Bethan;Campbell, Iain C.;Himmerich, Hubertus
炎症被认为在神经性厌食症 (AN) 中发挥病理生理学作用。在这项探索性横断面研究中，我们测量了 AN 患者 (n = 27) 和健康对照 (HC) (n = 13) 中 40 种炎症标志物（包括细胞因子、趋化因子和粘附分子）和脑源性神经营养因子 (BDNF) 的血清浓度。其中许多炎症标志物之前并未在 AN 患者中进行量化。评估了饮食失调（ED）和一般精神病理学症状。获得体重指数（BMI）和身体成分数据。与 HC 相比，AN 参与者的白介素 (IL)-6、IL-15 和血管细胞粘附分子 (VCAM)-1 浓度显着升高，BDNF、肿瘤坏死因子 (TNF)-β 和血管内皮生长因子 (VEGF)-A 浓度显着降低。年龄、体重指数和身体脂肪质量百分比被认为是其中几种炎症标志物的潜在混杂变量。特别有趣的是，AN 患者的大多数量化标志物没有变化，尽管他们体重严重不足，体内脂肪明显减少，并且具有临床上显着的 ED 症状以及严重的抑郁和焦虑症状。未来的研究应该检验我们研究结果的可重复性，并考虑其他潜在的混杂变量（例如吸烟和体力活动）对 AN 和炎症之间关系的影响。
Inflammation has been suggested to play a pathophysiological role in anorexia nervosa (AN). In this exploratory cross-sectional study, we measured serum concentrations of 40 inflammatory markers (including cytokines, chemokines, and adhesion molecules) and brain-derived neurotrophic factor (BDNF) in people with AN (n = 27) and healthy controls (HCs) (n = 13). Many of these inflammatory markers had not been previously quantified in people with AN. Eating disorder (ED) and general psychopathology symptoms were assessed. Body mass index (BMI) and body composition data were obtained. Interleukin (IL)-6, IL-15, and vascular cell adhesion molecule (VCAM)-1 concentrations were significantly elevated and concentrations of BDNF, tumor necrosis factor (TNF)-beta, and vascular endothelial growth factor (VEGF)-A were significantly lower in AN participants compared to HCs. Age, BMI, and percentage body fat mass were identified as potential confounding variables for several of these inflammatory markers. Of particular interest is that most of the quantified markers were unchanged in people with AN, despite them being severely underweight with evident body fat loss, and having clinically significant ED symptoms and severe depression and anxiety symptoms. Future research should examine the replicability of our findings and consider the effect of additional potential confounding variables, such as smoking and physical activity, on the relationship between AN and inflammation.