Hypoadiponectinemia is an independent risk factor for hypertension
Hypoadiponectinemia is an independent risk factor for hypertension
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DOI：
10.1161/01.hyp.0000129281.03801.4b
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发表时间：
2004-06-01
期刊：
影响因子：
8.3
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Iwashima, Y;Katsuya, T;Ogihara, T
脂联素是代谢综合征的关键分子之一，其浓度在肥胖、2型糖尿病和冠状动脉疾病中降低。遗传学研究表明，2个多态性（I164T和G276T）与脂联素浓度和糖尿病有关。为了检查脂联素是否从遗传或生物学角度影响高血压，我们进行了一项病例对照研究。共有 446 名诊断为高血压 (HT) 的男性病例和 312 名血压正常 (NT) 的男性参与了这项研究。使用酶联免疫吸附测定系统测量血浆脂联素浓度。采用TaqMan聚合酶链反应法测定单核苷酸多态性。调整混杂因素后，HT 组脂联素浓度显着降低（HT：5.2 +/- 0.2 mug/mL；NT：6.1 +/- 0.2 mug/mL；P < 0.001）。此外，多元回归分析表明低脂联素血症是高血压的独立危险因素（P < 0.001）。无论胰岛素抵抗如何，血压正常时的血压与脂联素浓度呈负相关。携带I164T多态性TC基因型的受试者中，脂联素浓度显着较低（TC：2.6±0.9μg/mL；TT：5.5±0.1μg/mL；P<0.01），并且大多数患有高血压。相反，G276T 多态性与脂联素浓度或高血压无关。总之，低脂联素血症是男性易患高血压的一个标志。
Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2 +/- 0.2 mug/mL; NT: 6.1 +/- 0.2 mug/mL; P < 0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P < 0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6 +/- 0.9 mug/mL; TT: 5.5 +/- 0.1 mug/mL; P < 0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.