HPLC analysis of anti-malaria agent, chloroquine in blood and tissue from forensic autopsy cases in Tanzania
HPLC analysis of anti-malaria agent, chloroquine in blood and tissue from forensic autopsy cases in Tanzania
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DOI：
10.1016/j.legalmed.2004.10.002
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发表时间：
2005-03-05
期刊：
影响因子：
1.5
通讯作者：
Tsunenari, Shigeyuki
中科院分区：
文献类型：
--
作者：
Yonemitsu, Kosei;Koreeda, Ako;Tsunenari, Shigeyuki
对坦桑尼亚达累斯萨拉姆的3例法医尸检病例进行了血样和组织中抗疟药氯喹(CQ)的高效液相色谱分析。3例股静脉血中CQ浓度分别为8.5、48.4和43.8微克/毫升，死亡原因为急性CQ中毒。血CQ水平有很大的部位依赖性变化。右心血样含量很高，这可能是由于药物生前分布不完全或死后从肝脏及其周围血扩散所致，因为CQ在肝脏中的含量很高。自杀和意外的CQ中毒非常常见，CQ是坦桑尼亚法医毒理学领域的一种非常重要的化学品。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
HPLC analysis of anti-malaria agent, chloroquine (CQ) in blood and tissues with a simple HCI back extraction method was applied to three forensic autopsy cases in Dar es Salaam, Tanzania. CQ concentrations in femoral vein blood were 8.5, 48.4 and 43.8 mu g/ml in three cases, respectively, which were high enough to attribute the cause of deaths to an acute CQ poisoning. There were great site dependent variations in blood CQ levels. The right heart blood samples were very high, which may be explained by incomplete distribution of the drug before death or postmortem diffusion from liver and its surrounding blood, as high CQ levels were remarkable in the liver. Suicidal and accidental CQ poisonings are very common and CQ is a very important chemical in the field of forensic toxicology in Tanzania. (c) 2004 Elsevier Ireland Ltd. All rights reserved.