Fgf Signaling Components Are Associated With Muscles and Tendons During Limb Development
Fgf Signaling Components Are Associated With Muscles and Tendons During Limb Development
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DOI：
10.1002/dvdy.21946
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发表时间：
2009-05-01
影响因子：
2.5
通讯作者：
Duprez, Delphine
中科院分区：
文献类型：
--
作者：
Eloy-Trinquet, Sophie;Wang, Hui;Duprez, Delphine
肌肉-肌腱相互作用对于建立功能性肌肉骨骼系统是重要的。Fgf 4和Fgf 8在肢体发育过程中在肌肉和肌腱边界区域表达，表明Fgf信号通路在肌肉和肌腱相互作用中的潜在作用。我们已经研究了成纤维细胞生长因子的顺式表达组组件在肌肉和肌腱形成的脊椎动物肢体发育。我们观察到，成纤维细胞生长因子信号的转录效应子，Pea 3，和成纤维细胞生长因子信号的调制器，Sprouty 1和2，在肌肉和肌腱中表达，并且它们的表达在鸡和小鼠肢体的肌腱连接处增强。对Pax 3突变小鼠无肌肉肢体中Pea 3和Sprouty基因表达的分析表明，主要表达在肌肉中，但也揭示了肌腱中Pea 3和Sprouty的表达依赖于肌肉。最后，我们的数据表明，Fgf 4正调控鸡肢间充质中Pea 3，Sprouty 1和2的表达。Developmental Dynamics 238：1195-1206，2009. (C)2009威利-利斯公司
Muscle-tendon interactions are important for the establishment of a functional musculoskeletal system. Fgf4 and Fgf8 are expressed in muscle and tendon boundary regions during limb development, suggesting a potential role for Fgf signaling pathway in muscle and tendon interactions. We have examined the expression of Fgf syn-expression group components during muscle and tendon formation of vertebrate limb development. We observed that the transcriptional effector of Fgf signaling, Pea3, and the modulators of Fgf signal, Sprouty1 and 2, were expressed in muscles and tendons and that their expression was enhanced at the myotendinous junctions in chick and mouse limbs. Analysis of Pea3 and Sprouty gene expression in muscleless limbs of Pax3 mutant mice indicated a major expression in muscles but also revealed that the Pea3 and Sprouty expression in tendons depended on muscles. Finally, our data showed that Fgf4 positively regulated Pea3, Sprouty1, and 2 expression in chick limb mesenchyme. Developmental Dynamics 238:1195-1206, 2009. (C) 2009 Wiley-Liss, Inc.