Improvement of cardiac performance by carboxylic ionophore monensin in greyhound and mongrel dogs.
Improvement of cardiac performance by carboxylic ionophore monensin in greyhound and mongrel dogs.
复制标题
羧基离子载体莫能菌素改善灵缇犬和杂种狗的心脏性能。
DOI：
10.1007/bf00500018
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Pressman,BC
中科院分区：
文献类型：
--
作者：
Fahim,M;Pressman,BC
强心离子载体莫能菌素对冠状动脉血流量，心输出量，左心室（LV）耗氧量，左心室收缩力和动脉血压的影响进行了测定，并与戊巴比妥麻醉下的杂种狗进行了比较。静脉注射100 μg/kg莫能菌素后，所有参数均升高，灰狗在冠状动脉血流量峰值、LV收缩力和心输出量方面显示出相对更大的反应。计算的LV机械功的增加比例大于LV耗氧量的相应增加，因此灰狗的衍生指数（外部机械效率）从初始值0.165迅速上升至0.285（73%）;杂种犬在同一时间段内从0.094上升至0.120（28%）。两种狗的反应的差异主要归因于灰狗与未经训练的杂种狗相比心脏尺寸更大和运动训练。
The effects of the cardiotonic ionophore monensin on coronary blood flow, cardiac output, left ventricular (LV) O2consumption, LV contractility and arterial blood pressure were measured in greyhounds and compared with those in mongrel dogs under pentobarbital anaesthesia. Following intravenous injection of 100 μg/kg monensin, all parameters rose, the greyhounds showing a relatively greater response in peak values of coronary blood flow, LV contractility and cardiac output. The increase in the calculated LV mechanical work was proportionately greater than the corresponding increase in LV O2consumption, hence the derived index, external mechanical efficiency, rose rapidly from an initial value of 0.165 to 0.285 (73%) in greyhounds; mongrel dogs showed a more modest rise from 0.094 to 0.120 (28%) during the same interval. The difference in the responses in the two breeds of dogs are attributed mainly to larger heart size and exercise training in greyhounds as compared with untrained mongrel dogs.