Navigated Transcranial Magnetic Stimulation: A Biologically Based Assay of Lower Extremity Impairment and Gait Velocity.
Navigated Transcranial Magnetic Stimulation: A Biologically Based Assay of Lower Extremity Impairment and Gait Velocity.
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DOI：
10.1155/2017/6971206
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发表时间：
2017
影响因子：
3.1
通讯作者：
Page SJ
中科院分区：
文献类型：
--
作者：
Peters HT;Dunning K;Belagaje S;Kissela BM;Ying J;Laine J;Page SJ
目标. (a)确定运动诱发电位（MEP）幅度、MEP潜伏期、下肢（LE）损伤和步态速度之间的关联，以及（B）确定可检测MEP信号的存在与LE损伤和步态速度之间的关联。法对35例慢性稳定性LE轻偏瘫患者进行TMS、Fugl-Meyer损伤量表（LE FM）LE部分和10米步行试验。我们记录的存在，振幅和潜伏期的MEP在受影响的胫骨前肌（TA）和比目鱼肌（SO）。结果MEP的存在与TA和SO中较高的LEFM评分相关。MEP潜伏期在LEFM较低和行走困难的受试者中较大。结论MEP潜伏期似乎是LE损伤和步态的指标。意义我们的研究结果支持使用TMS，特别是MEP潜伏期，作为一个连续的LE结果测量和预后技术的概念。
Objectives. (a) To determine associations among motor evoked potential (MEP) amplitude, MEP latency, lower extremity (LE) impairment, and gait velocity and (b) determine the association between the presence of a detectable MEP signal with LE impairment and with gait velocity. Method. 35 subjects with chronic, stable LE hemiparesis were undergone TMS, the LE section of the Fugl-Meyer Impairment Scale (LE FM), and 10-meter walk test. We recorded presence, amplitude, and latency of MEPs in the affected tibialis anterior (TA) and soleus (SO). Results. MEP presence was associated with higher LEFM scores in both the TA and SO. MEP latency was larger in subjects with lower LEFM and difficulty walking. Conclusion. MEP latency appears to be an indicator of LE impairment and gait. Significance. Our results support the precept of using TMS, particularly MEP latency, as an adjunctive LE outcome measurement and prognostic technique.