Reduced Skeletal Muscle Volume and Increased Skeletal Muscle Fat Deposition Characterize Diabetes in Individuals after Pancreatitis: A Magnetic Resonance Imaging Study.
Reduced Skeletal Muscle Volume and Increased Skeletal Muscle Fat Deposition Characterize Diabetes in Individuals after Pancreatitis: A Magnetic Resonance Imaging Study.
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DOI：
10.3390/diseases8030025
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发表时间：
2020-07-01
期刊：
影响因子：
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通讯作者：
Petrov MS
中科院分区：
文献类型：
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作者：
Modesto AE;Ko J;Stuart CE;Bharmal SH;Cho J;Petrov MS
背景：骨骼肌与2型糖尿病的发病机制有关，但在胰腺炎后的糖尿病中从未被研究过。目的是研究胰腺炎后腰大肌体积(PMV)与糖尿病的关系，以及它与异位脂肪表型和胰岛素特征的关系。方法：对胰腺炎发作后的个体和健康个体进行横断面研究。所有参与者都接受了磁共振成像，在此基础上得出PMV、骨骼肌脂肪沉积(SMFD)以及肝脏和胰腺内脂肪沉积。采集空腹和餐后血样，计算胰岛素敏感性和分泌指数。进行了线性回归分析，调整了可能的混杂因素(年龄、性别、身体成分、合并症、胰岛素使用等)。结果：共153名受试者参与研究。糖尿病组较健康对照组PMV显著降低(β=−为30.0，p=0.034)。SMFD与PMV显著负相关(在调整最多的模型中，β=−为3.1p<；0.001)。松田胰岛素敏感性指数与PMV显著相关(β=1.6，p=0.010，在调整最多的模型中)。结论：胰腺炎后糖尿病患者的特点是PMV降低。胰腺炎后PMV降低与SMFD增加和胰岛素敏感性降低有关。
Background: Skeletal muscle has been implicated in the pathogenesis of type 2 diabetes but it has never been investigated in diabetes after pancreatitis. The aim was to investigate the relationship between psoas muscle volume (PMV) and diabetes in individuals after pancreatitis, as well as its associations with ectopic fat phenotypes and insulin traits. Methods: Individuals after an attack of pancreatitis and healthy individuals were studied in a cross-sectional fashion. All participants underwent magnetic resonance imaging, based on which PMV, skeletal muscle fat deposition (SMFD), as well as liver and intra-pancreatic fat depositions were derived. Fasting and postprandial blood samples were collected to calculate indices of insulin sensitivity and secretion. Linear regression analyses were conducted, adjusting for possible confounders (age, sex, body composition, comorbidities, use of insulin, and others). Results: A total of 153 participants were studied. PMV was significantly decreased in the diabetes group compared with healthy controls (β = −30.0, p = 0.034 in the most adjusted model). SMFD was significantly inversely associated with PMV (β = −3.1, p < 0.001 in the most adjusted model). The Matsuda index of insulin sensitivity was significantly directly associated with PMV (β = 1.6, p = 0.010 in the most adjusted model). Conclusions: Diabetes in individuals after pancreatitis is characterized by reduced PMV. Reduced PMV is associated with increased SMFD and decreased insulin sensitivity in individuals after pancreatitis.