Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy
Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy
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DOI：
10.2215/cjn.13841215
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发表时间：
2016-08-01
影响因子：
9.8
通讯作者：
Johnson, Richard J.
中科院分区：
文献类型：
--
作者：
Glaser, Jason;Lemery, Jay;Johnson, Richard J.
气候变化导致全球平均气温在上个世纪大幅上升0.8 -0.9摄氏度，并与热浪（极端高温事件）的频率和严重程度大幅增加有关。气候变化也越来越多地与有害的人类健康联系在一起。与气候相关的极端高温暴露的后果之一是脱水和体积损失，导致预先存在的慢性疾病恶化以及完全热衰竭和中暑的急性死亡。最近的研究还表明，经常性的热暴露与体力消耗和水合作用不足可导致CKD，这与糖尿病，高血压或GN引起的CKD不同。与热应激肾病一致的CKD流行病现在正在世界各地发生。在这里，我们描述了这种疾病，讨论了它出现的位置，将其与温度升高联系起来，并讨论了预防这种疾病的持续努力。热应激肾病可能是全球变暖引起的第一批流行病之一。受影响地区的政府、行业和卫生政策制定者应更加重视职业和社区干预。
Climate change has led to significant rise of 0.8 degrees C-0.9 degrees C in global mean temperature over the last century and has been linked with significant increases in the frequency and severity of heat waves (extreme heat events). Climate change has also been increasingly connected to detrimental human health. One of the consequences of climate-related extreme heat exposure is dehydration and volume loss, leading to acute mortality from exacerbations of pre-existing chronic disease, as well as from outright heat exhaustion and heat stroke. Recent studies have also shown that recurrent heat exposure with physical exertion and inadequate hydration can lead to CKD that is distinct from that caused by diabetes, hypertension, or GN. Epidemics of CKD consistent with heat stress nephropathy are now occurring across the world. Here, we describe this disease, discuss the locations where it appears to be manifesting, link it with increasing temperatures, and discuss ongoing attempts to prevent the disease. Heat stress nephropathy may represent one of the first epidemics due to global warming. Government, industry, and health policy makers in the impacted regions should place greater emphasis on occupational and community interventions.