Transcriptional characterization of the antioxidant response of Mycobacterium tuberculosis in vivo and during adaptation to hypoxia in vitro
Transcriptional characterization of the antioxidant response of Mycobacterium tuberculosis in vivo and during adaptation to hypoxia in vitro
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DOI：
10.1016/j.tube.2007.08.007
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发表时间：
2008-01-01
期刊：
影响因子：
3.2
通讯作者：
Gennaro, Maria L.
中科院分区：
文献类型：
--
作者：
Shi, Lanbo;Sohaskey, Charles D.;Gennaro, Maria L.
Transcriptional profiling of antioxidant genes of Mycobacterium tuberculosis was performed by real-time RT-PCR during mouse tung infection and during adaptation to gradual oxygen depletion in vitro. M. tuberculosis genes involved in major detoxification pathways of oxidative stress were not up-regutated during chronic mouse lung infection, which is established in response to expression of host adaptive immunity. This result suggests that a major function of bacterial antioxidant enzymes is to protect from oxidants generated during the early, acute phase of infection. In vivo transcription profiles of bacterial antioxidant enzymes differed from those seen under adaptation to low oxygen in vitro, indicating differences between growth arrest in vivo and that induced by hypoxia in vitro. (c) 2007 Elsevier Ltd. All rights reserved.
