Prevalence of Isolates of Streptococcus pneumoniae Putative Serotype 6E in South Korea
Prevalence of Isolates of Streptococcus pneumoniae Putative Serotype 6E in South Korea
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DOI：
10.1128/jcm.00228-14
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发表时间：
2014-06-01
影响因子：
9.4
通讯作者：
Ko, Kwan Soo
中科院分区：
文献类型：
--
作者：
Baek, Jin Yang;Park, In Ho;Ko, Kwan Soo
调查了三个时期（1996年至2001年、2004年至2006年和2008年至2009年）从韩国医院收集的1，206株肺炎链球菌临床分离株中血清组6的患病率。血清组6分离株的数量在三个时期内从9.7%增加到17.5%。6A、6D血清型比例明显增加，6B血清型比例下降。24株（2.0%）被分型为最近确定的推定血清型6E或血清型6B的遗传变异。结果表明，尽管引入了先前在韩国进行的研究中观察到的PCV 7疫苗，但血清型6B的频率没有变化，这可能主要是由于在血清型6B中不适当地纳入了推定的血清型6E。除了3个血清型6E分离株外，所有分离株均属于CC90，表明其克隆扩增。
The prevalence of serogroup 6 among 1,206 Streptococcus pneumoniae clinical isolates collected from Korean hospitals over three periods (1996 to 2001, 2004 to 2006, and 2008 to 2009) was investigated. The number of serogroup 6 isolates increased from 9.7 to 17.5% over the three periods. While the proportion of serotype 6A and 6D isolates increased significantly, that of serotype 6B isolates decreased. Twenty-four isolates (2.0%) were typed as the recently identified putative serotype 6E or genetic variants of serotype 6B. The results suggest that the lack of change in frequency of serotype 6B, in spite of the introduction of the PCV7 vaccine as seen in previous studies in South Korea, might be due mainly to the improper inclusion of putative serotype 6E in serotype 6B. All but three serotype 6E isolates belonged to CC90, indicating their clonal expansion.