Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders
Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders
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DOI：
10.1016/j.schres.2007.04.014
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发表时间：
2007-08
影响因子：
4.5
通讯作者：
V. Vostrikov;N. Uranova;D. Orlovskaya
中科院分区：
文献类型：
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作者：
V. Vostrikov;N. Uranova;D. Orlovskaya
在精神分裂症（SCH）、双相情感障碍（BPD）和抑郁症（MDD）患者的前额叶皮层（PFC）中，已报道了少突胶质细胞的凋亡缺陷。此外，在SCH和情绪障碍的第III层中检测到锥体神经元的尺寸减小。由于少突胶质细胞对神经元有营养影响，在这些疾病中报告的神经元大小减少可能与神经元周少突胶质细胞亚群的缺陷有关。方法采用尼氏染色法，观察SCH、BPD、MDD和正常对照组锥体神经元少突胶质卫星细胞的数目和第III层（Brodmann 'sarea9）锥体神经元的大小。斯坦利基金会神经病理学协会的大脑收集，包括15例，在每四个groupsused.NUBTSWe检测到一个突出的和显着的减少，在亚层IIIa，IIIb和IIIc的神经少突胶质细胞的SCH，BPD和MDD相比，控制。BPD组与SCH组和MDD组相比差异有统计学意义。各精神病组和对照组之间在亚层IIIa、IIIb、IIIc中锥体神经元的体积无显著差异。只有BPD组表现出显着较小的神经元大小在子层IIIc相比，controls.CONCLUSIONSOUR的数据提供了证据，为赤字的神经少突胶质细胞在严重的精神障碍，可能发挥关键作用的病理生理学的SCH，BPD和MDD。
OBJECTIVEA deficit of oligodendrocytes has been reported in the prefrontal cortex (PFC) in schizophrenia (SCH), bipolar disorder (BPD) and major depression (MDD). Also, a decreased size of pyramidal neurons has been detected in layer III in SCH and in mood disorders. Since oligodendrocytes have a trophic influence on neurons, reduced neuronal size reported in these disorders might be associated with the deficit in subpopulation of perineuronal oligodendrocytes. We hypothesized that deficit of perineuronal oligodendrocytes might occur in SCH and mood disorders.METHODWe estimated the number of oligodendroglial satellites of pyramidal neurons and the size of pyramidal neurons in layer III (Brodmann's area 9) in Nissl stained sections in SCH, BPD, MDD and normal controls. The Stanley Foundation Neuropathology Consortium brain collection consisted of 15 cases in each of four groups was used.RESULTSWe detected a prominent and significant reduction in the number of perineuronal oligodendrocytes in the sublayers IIIa, IIIb and IIIc in SCH, BPD and MDD as compared to controls. The BPD group differed significantly from SCH group and from MDD group. There were no significant differences in somal sizes of pyramidal neurons in the sublayers IIIa, IIIb, IIIc between each of the psychiatric groups and the control group. Only BPD group showed significantly smaller neuronal size in sublayer IIIc as compared to controls.CONCLUSIONSOur data provide evidence for a deficit of perineuronal oligodendrocytes in severe mental disorders that may play a key role in the pathophysiology of SCH, BPD and MDD.