Total Syntheses of Crinipellins Enabled by Cobalt-Mediated and Palladium-Catalyzed Intramolecular Pauson-Khand Reactions
Total Syntheses of Crinipellins Enabled by Cobalt-Mediated and Palladium-Catalyzed Intramolecular Pauson-Khand Reactions
复制标题
钴介导和钯催化的分子内 Pauson-Khand 反应实现 Crinipellins 的全合成
DOI：
10.1002/anie.201805143
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发表时间：
2018-07-09
影响因子：
16.6
通讯作者：
Yang, Zhen
中科院分区：
文献类型：
--
作者：
Huang, Zhihui;Huang, Jun;Yang, Zhen
描述了天然存在的有效抗生素化合物（-）-crinipellinA和（-）-crinipellinB的有效全合成。通过硫脲/钯催化的Pauson-Khand反应，构建了一个关键的高级中间体，一个完全官能化的四醌核。该中间体可以作为共同的中间体，用于crinipellin家族的其他成员的集体全合成。
Efficient total syntheses of the naturally occurring, potent antibiotic compounds (-)-crinipellinA and (-)-crinipellinB are described. The key advanced intermediate, a fully functionalized tetraquinane core, was constructed by a novel thiourea/palladium-catalyzed Pauson-Khand reaction. This intermediate can serve as a common intermediate for the collective total synthesis of other members of the crinipellin family.