Changes in Choroidal Blood Flow by Diurnal Variation in Healthy Young Adults
Changes in Choroidal Blood Flow by Diurnal Variation in Healthy Young Adults
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DOI：
10.2174/18743641-v17-e230214-2022-53
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发表时间：
2023-01-01
影响因子：
0.3
通讯作者：
Yoshitomi, Takeshi
中科院分区：
文献类型：
--
作者：
Hashimoto, Yuki;Ishimaru, Yumi;Yoshitomi, Takeshi
背景：对健康眼睛脉络膜循环动力学的昼夜变化知之甚少。目的：本研究旨在利用激光散斑血流成像技术阐明健康参与者脉络膜循环血流动力学变化的昼夜变化。方法：这项前瞻性研究包括 14 名健康年轻人（21.9 +/- 4.0 岁）的左眼。平均模糊率是相对血流速度的定量指标，通过激光散斑血流成像测量。在24小时内每3小时评估8个点的脉络膜血流速度、黄斑中心凹下脉络膜厚度、眼压、收缩压、舒张压、平均血压和眼灌注压的黄斑平均模糊率。此外，还调查了白天和夜间各参数的差异。结果：眼压、收缩压、舒张压、平均血压、眼灌注压和黄斑平均模糊率在下午6点最高，黄斑中心凹下脉络膜厚度在下午6点最薄。平均模糊率与眼压、舒张压、平均血压呈显着正相关。此外，白天的眼压、收缩压、舒张压、平均血压、眼灌注压和平均模糊率显着高于夜间，脉络膜厚度显着低于夜间。结论：这些结果表明，健康眼睛的自主神经系统的体循环的昼夜变化会导致脉络膜循环血流动力学的变化。
Background: Little is known about the diurnal variation in choroidal circulatory dynamics in healthy eyes.Objective: This study aimed to clarify the diurnal variation in choroidal circulatory hemodynamic changes in healthy participants using laser speckle flowgraphy.Methods: This prospective study included the left eye of 14 healthy young adults (21.9 +/- 4.0 years). The mean blur rate, a quantitative index of the relative blood flow velocity, was measured by laser speckle flowgraphy. The macular mean blur rate of choroidal blood flow velocity, subfoveal choroidal thickness, intraocular pressure, systolic blood pressure, diastolic blood pressure, mean blood pressure, and ocular perfusion pressure were evaluated at eight points every 3 h over a 24-h period. In addition, differences in each parameter between daytime and night were also investigated.Results: Intraocular pressure, systolic blood pressure, diastolic blood pressure, mean blood pressure, ocular perfusion pressure, and macular mean blur rate were highest at 6 PM, and subfoveal choroidal thickness was thinnest at 6 PM. There was a significant positive correlation between mean blur rate and intraocular pressure, diastolic blood pressure, and mean blood pressure. Furthermore, intraocular pressure, systolic blood pressure, diastolic blood pressure, mean blood pressure, ocular perfusion pressure, and mean blur rate were significantly higher and choroidal thickness significantly lower during daytime than at night.Conclusion: These results suggest that choroidal circulation hemodynamics change with diurnal variations in systemic circulation involving the autonomic nervous system in healthy eyes.