Interaction between behavioral despair and addictive behaviors in rats
Interaction between behavioral despair and addictive behaviors in rats
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DOI：
10.1016/j.physbeh.2010.10.002
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发表时间：
2011-01
影响因子：
2.9
通讯作者：
Meng Tian;Rongrong Mao;Li-Ping Wang;Qi-Xin Zhou;Jun Cao;Lin Xu
中科院分区：
文献类型：
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作者：
Meng Tian;Rongrong Mao;Li-Ping Wang;Qi-Xin Zhou;Jun Cao;Lin Xu
有人认为，抑郁症既可能是药物滥用的原因，也可能是药物滥用的结果，这为药物滥用者抑郁症患病率几乎是普通人群的三倍这一事实提供了可能的解释。然而，抑郁症和药物滥用之间的相互作用尚未完全阐明。为了研究行为绝望和成瘾行为之间的相互作用，我们使用波尔索尔特强迫游泳测试（FST）作为行为绝望模型，并使用吗啡条件位置偏好（CPP）和重复吗啡暴露作为成瘾行为模型。我们发现，暴露于标准 FST（第 0 天训练 15 分钟）而不是弱 FST（第 0 天训练 10 分钟）的大鼠表现出行为绝望，这选择性地增强吗啡 CPP (mCPP)，但不增强食物 CPP (fCPP)。抗抑郁药丙咪嗪（15mg/kg，腹腔注射）可阻止行为绝望，阻止标准 FST 强化吗啡 CPP。相反，在随后的标准 FST 中，重复暴露于吗啡（10mg/kg，皮下注射）6、12 或 20 天分别对不动时间减少、无影响或增加。此外，连续 20 天反复接触吗啡加剧了先前存在的行为绝望。因此，我们的研究结果表明，行为绝望可能会增加个体滥用阿片类药物的脆弱性，这反过来可能会加剧行为绝望。
It has been suggested that depression can be either a cause or a consequence of drug abuse, providing a possible explanation for the fact that the prevalence of depression is almost 3-fold higher in drug abusers than in the general population. However, the interaction between depression and drug abuse has not been fully elucidated. To examine the interaction between behavioral despair and addictive behaviors, we used the Porsolt's forced swim test (FST) as a model of behavioral despair, and we used morphine conditioned place preference (CPP) and repeated morphine exposure as models of addictive behaviors. We found that rats exposed to a standard FST (15min on day 0 training) rather than a weak FST (10min on day 0 training) exhibited behavioral despair, which selectively potentiated morphine CPP (mCPP) but not food CPP (fCPP). The antidepressant imipramine (15mg/kg, i.p.), which blocked the behavioral despair, prevented the standard FST potentiated morphine CPP. Conversely, repeated exposure to morphine (10mg/kg, s.c.) for 6, 12 or 20days decreased, had no effect on, or increased the immobility time, respectively, in the subsequent standard FST. Furthermore, repeated morphine exposure for 20days exacerbated the pre-existing behavioral despair. Thus, our findings suggest that behavioral despair may increase the vulnerability of individuals to opiate abuse, which may in turn enhance behavioral despair.