Sensitivity of T2-weighted FSE sequences towards physiological iron depositions in normal brains at 1.5 and 3.0 T
Sensitivity of T2-weighted FSE sequences towards physiological iron depositions in normal brains at 1.5 and 3.0 T
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DOI：
10.1007/s00330-004-2241-4
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发表时间：
2004-06-01
影响因子：
5.9
通讯作者：
Tombach, B
中科院分区：
文献类型：
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作者：
Allkemper, T;Schwindt, W;Tombach, B
为评价1.5T和3.0T磁共振成像场强下正常脑组织T2加权快速自旋回波(FSE)序列对生理性铁沉积的敏感性，比较了6例模体(n=6)和10例健康志愿者(n=10)在1.5和3.0T临床成像系统(Gyrocan Intera，Philps Medical Systems，Best，荷兰)获得的快速自旋回波(FSE)T2加权序列。计算不同浓度的氧化铁掺杂试管和有生理性铁沉积的脑区(红核、黑质、苍白球)的对比噪声比(CNR)。通过比较在任一磁场强度下可见低信号的程度，对含铁脑结构的表观敏感性效应进行了定性分析。在3.0T时，氧化铁管和含铁脑区的平均CNR显著降低。定性分析证实了这些测量结果。检测和诊断铁含量改变的大脑疾病，如神经退行性帕金森病(NPD)或脑出血，应受益于T2加权FSE序列对3.0T敏感性效应的敏感性增加。
To evaluate the sensitivity of T2-weighted fast spin-echo (FSE) sequences to physiological iron depositions in normal brains at MR imaging field strengths of 1.5 and 3.0 T. T2-weighted FSE sequences acquired at 1.5 and 3.0 T clinical imaging systems (Gyroscan Intera, Philips Medical Systems, Best, The Netherlands) were compared by means of MRI in phantoms (n=6) and healthy volunteers (n=10). Contrast-to-noise ratios (CNRs) of tubes doped with iron oxides at different concentrations and of brain areas with physiological iron depositions (nucleus ruber, substantia nigra, globus pallidus) were calculated for either field strength. Apparent susceptibility effects of iron-containing brain structures were qualitatively analyzed by comparing the degree of visible hypointensity by a score system at either field strength. The mean CNR of iron oxide tubes and iron-containing brain areas was significantly decreased at 3.0 T. Qualitative analysis confirmed these measurements. Detection and diagnosis of brain disorders with altered iron content such as neurodegenerative parkinsonian disorders (NPD) or intracerebral hemorrhage should benefit from the increased sensitivity of T2-weighted FSE sequences to susceptibility effects at 3.0 T.